C₇₀H₈₀N₂O₁₅

Base Information

• Chemical Name: C₇₀H₈₀N₂O₁₅
• CAS No.: 1253375-59-5
• Molecular Formula: C₇₀H₈₀N₂O₁₅
• Molecular Weight: 1189.41
• Mol file: 1253375-59-5.mol

Synonyms:C₇₀H₈₀N₂O₁₅

Chemical Property of C₇₀H₈₀N₂O₁₅

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₇₀H₈₀N₂O₁₅

There total 5 articles about C₇₀H₈₀N₂O₁₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

trans-N-tert-butyloxycarbonyl-4-hydroxy-4-[2,3,5-tribenzyl-β-L-arabinofuranosyl]-L-proline (1253376-06-5) + trans-4-hydroxy-4-[2,3,5-tribenzyl-β-L-arabinofuranosyl]-L-proline allyl ester (1253376-13-4) → C70H80N2O15 (1253375-59-5)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/ol102112z

Reference yield:

trans-4-hydroxy-4-[2,3,5-tribenzyl-β-L-arabinofuranosyl]-L-proline allyl ester (1253376-13-4) + C34H39NO7*C2HF3O2 → C70H80N2O15 (1253375-59-5)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; at 0 - 30 ℃; Reagent/catalyst; Temperature; Inert atmosphere;

DOI:10.1021/jo501191b

Reference yield:

trans-N-tert-butyloxycarbonyl-4-hydroxy-4-[2,3,5-tribenzyl-β-L-arabinofuranosyl]-L-proline allyl ester → C70H80N2O15 (1253375-59-5)

Guidance literature:

Multi-step reaction with 2 steps

1: tetra(n-butyl)ammonium hydroxide; water / tetrahydrofuran / 1.5 h / 20 °C

2: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / dichloromethane / 0 - 30 °C / Inert atmosphere

With tetra(n-butyl)ammonium hydroxide; water; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jo501191b

upstream raw materials:

trans-N-tert-butyloxycarbonyl-4-hydroxy-4-[2,3,5-tribenzyl-β-L-arabinofuranosyl]-L-proline

trans-4-hydroxy-4-[2,3,5-tribenzyl-β-L-arabinofuranosyl]-L-proline allyl ester

(4R)-hydroxypyrrolidine-1,(2S)-dicarboxylic acid 2-allyl ester 1-tert-butyl ester