Technology Process of N-tert-butoxycarbonyl-N'-(2-chlorophenyl)-N'-(4-fluorophenyl)hydrazine
There total 6 articles about N-tert-butoxycarbonyl-N'-(2-chlorophenyl)-N'-(4-fluorophenyl)hydrazine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
tert-butyl 2-(2-chlorophenyl)diazene-1-carboxylate; 4-fluoroboronic acid;
With
copper(II) acetate monohydrate;
In
methanol;
for 0.0833333h;
Reflux;
Inert atmosphere;
With
silica gel;
In
methanol;
at 20 ℃;
for 0.0833333h;
Inert atmosphere;
DOI:10.1055/s-0030-1260082
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: pyridine; N-Bromosuccinimide / dichloromethane / 0.5 h / 0 °C / Inert atmosphere
2.1: copper(II) acetate monohydrate / methanol / 0.08 h / Reflux; Inert atmosphere
2.2: 0.08 h / 20 °C / Inert atmosphere
With
pyridine; N-Bromosuccinimide; copper(II) acetate monohydrate;
In
methanol; dichloromethane;
DOI:10.1055/s-0030-1260082
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: hydrogenchloride; tin(II) chloride dihdyrate; water / 2.5 h / 0 °C / Inert atmosphere
2.1: tetrahydrofuran / 20 °C / Inert atmosphere
3.1: pyridine; N-Bromosuccinimide / dichloromethane / 0.5 h / 0 °C / Inert atmosphere
4.1: copper(II) acetate monohydrate / methanol / 0.08 h / Reflux; Inert atmosphere
4.2: 0.08 h / 20 °C / Inert atmosphere
With
pyridine; hydrogenchloride; N-Bromosuccinimide; tin(II) chloride dihdyrate; water; copper(II) acetate monohydrate;
In
tetrahydrofuran; methanol; dichloromethane;
DOI:10.1055/s-0030-1260082
