823188-36-9

Upstream product

• 95-51-2 o-chloroaniline 
• 24424-99-5 di-tert-butyl dicarbonate 
• 10449-07-7 (2-chlorophenyl)hydrazine 
• 857595-49-4 o-chloronitroaniline 
• 41052-75-9 o-chlorophenylhydrazine hydrochloride 

Downstream Products

• 70777-07-0 7-chloro-2,3-diphenyl-1H-indole 
• 1338369-88-2 N-tert-butoxycarbonyl-N'-benzyl-N'-(2-chlorophenyl)hydrazine 
• 857796-41-9 N-benzyl-N-(2-chlorophenyl)hydrazine 
• 2677-05-6 (2-chlorophenyl)(4-fluorophenyl)amine 
• 98018-66-7 N-benzyl-2-chloroaniline 
• 1338369-78-0 N-(2-chlorophenyl)-N-(4-fluorophenyl)hydrazine 
• 1338369-65-5 N-tert-butoxycarbonyl-N'-(2-chlorophenyl)-N'-(4-fluorophenyl)hydrazine 
• 1338369-59-7 tert-butyl 2-(2-chlorophenyl)diazene-1-carboxylate 
• 928053-47-8 N'-(2-chloro-phenyl)-N'-((1S,4S)-4,7,7-trimethyl-3-oxo-bicyclo[2.2.1]heptane-2-carbonyl)-hydrazinecarboxylic acid tert-butyl ester 
• 823189-15-7 2-(2-chloro-phenyl)-pyrazolidine-1-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

Hydrogen peroxide based oxidation of hydrazines using HBr catalyst

Azo compounds (RN = NR′) are an important class of organic molecules that find wide application in organic synthesis. Herein, we report an efficient, practical and metal-free oxidation of hydrazines (RNH-NHR’) to azo compounds using 5 mol% HBr and hydrogen peroxide as terminal oxidant. This new method has been demonstrated by 40 examples with excellent yields. In addition, we showcased two examples of the one-pot sequential reactions involving our hydrazine oxidation/hydrolysis/Heck reaction or Cu-catalyzed N-arylation with aryl boronic acid. The distinct advantages of this protocol include metal-free catalysis, waste prevention, and easy operation.

Synthesis of Hydrazines via Radical Generation and Addition of Azocarboxylic tert -Butyl Esters

A new chemistry of azo compounds that is a radical generation and addition in situ of azocarboxylic tert-butyl esters to synthesize hydrazines has been described. The protocol provides a novel strategy for the synthesis of various hydrazines. The advantag

Microwave-Assisted Rapid One-Pot Synthesis of Fused and Non-Fused Indoles and 5-[18F]Fluoroindoles from Phenylazocarboxylates

Substituted indoles can be prepared from phenylazocarboxylates through a rapid one-pot sequence featuring a microwave-assisted Fischer indole synthesis as a key step. Considering that the phenylazocarboxylates may beforehand be modified by mild nucleophilic aromatic substitution, including the introduction of [18F]fluoride, the overall strategy offers an attractive new access to 5-[18F]fluoroindoles.

Photoinduced cleavage of N-N bonds of aromatic hydrazines and hydrazides by visible light

A photocatalytic system involving [Ru(bpyrz)(PFH, visible light, and air has been developed for cleavage of the N-N bonds of hydrazines and hydrazides. This catalytic system is generally effective for N,N-disubstituted hydrazine and hydrazide derivatives, including arylhydrazides, N-alkyl-N-arylhydrazines, and N,N-diarylhydrazines. The utility of this cleavage reaction has been demonstrated by synthesizing a variety of secondary aromatic amines. Georg Thieme Verlag Stuttgart ? New York.

Pyrazolones as inhibitors of 11B-hydroxysteroid dehydrogenase

Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, type II diabetes mellitus and metabolic syndrome.

TACHYKININ RECEPTOR ANTAGONISTS

The present invention relates to selective NK-1 receptor antagonists of Formula (I) or a pharmaceutically acceptable salt thereof, for the treatment of disorders associated with an excess of tachykinins.