2,2'-anhydro-1-(3'-deoxy-3'-bromo-5'-O-trityl-β-D-arabinofuranosyl)thymine

Base Information

• Chemical Name: 2,2'-anhydro-1-(3'-deoxy-3'-bromo-5'-O-trityl-β-D-arabinofuranosyl)thymine
• CAS No.: 145819-53-0
• Molecular Formula: C₂₉H₂₅BrN₂O₄
• Molecular Weight: 545.433
• Mol file: 145819-53-0.mol

Synonyms:2,2'-anhydro-1-(3'-deoxy-3'-bromo-5'-O-trityl-β-D-arabinofuranosyl)thymine

Chemical Property of 2,2'-anhydro-1-(3'-deoxy-3'-bromo-5'-O-trityl-β-D-arabinofuranosyl)thymine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,2'-anhydro-1-(3'-deoxy-3'-bromo-5'-O-trityl-β-D-arabinofuranosyl)thymine

There total 10 articles about 2,2'-anhydro-1-(3'-deoxy-3'-bromo-5'-O-trityl-β-D-arabinofuranosyl)thymine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

2,2'-anhydro-1-(3'-deoxy-3'-bromo-5'-O-trityl-β-D-arabinofuranosyl)-(5S,6S)-trans-5-bromo-6-hydroxy-5,6-dihydrothymine (145919-54-6) → 2,2'-anhydro-1-(3'-deoxy-3'-bromo-5'-O-trityl-β-D-arabinofuranosyl)thymine (145819-53-0)

Guidance literature:

With sodium hydrogencarbonate; triphenylphosphine; In N,N-dimethyl-formamide; for 1.16667h;

DOI:10.1246/cl.1992.2149

Reference yield: 85.3%

(5R,6R)-2,2'-anhydro-5-bromo-1-(3'-bromo-3'-deoxy-5'-O-trityl-β-D-arabinofuranosyl)-6-methoxy-5,6-dihydrothymine (159353-49-8) → 2,2'-anhydro-1-(3'-deoxy-3'-bromo-5'-O-trityl-β-D-arabinofuranosyl)thymine (145819-53-0)

Guidance literature:

With sodium hydrogencarbonate; triphenylphosphine; In N,N-dimethyl-formamide; for 0.166667h;

Reference yield: 85.0%

1-(2,3-anhydro-5-O-trityl-β-D-lyxofuranosyl)-2-O-methylthymine (142545-13-9) → 2,2'-anhydro-1-(3'-deoxy-3'-bromo-5'-O-trityl-β-D-arabinofuranosyl)thymine (145819-53-0)

Guidance literature:

With dilithium tetrabromocuprate; In tetrahydrofuran; for 43h; Ambient temperature;

DOI:10.1080/07328319308016204

upstream raw materials:

(5S,6R)-2,2'-anhydro-1-(3'-bromo-3'-deoxy-5'-O-trityl-β-D-arabinofuranosyl)-5,6-epoxy-5,6-dihydrothymine

(5R,6S)-2,2'-anhydro-1-(3'-bromo-3'-deoxy-5'-O-trityl-β-D-arabinofuranosyl)-5,6-epoxy-5,6-dihydrothymine

2,2'-anhydro-1-(3'-deoxy-3'-bromo-5'-O-trityl-β-D-arabinofuranosyl)-(5R,6R)-trans-5-bromo-6-hydroxy-5,6-dihydrothymine

2,2'-anhydro-1-(3'-deoxy-3'-bromo-5'-O-trityl-β-D-arabinofuranosyl)-(5S,6S)-trans-5-bromo-6-hydroxy-5,6-dihydrothymine

Downstream raw materials:

1-(2,3-anhydro-5-O-trityl-β-D-lyxofuranosyl)-2-O-methylthymine

1-(2,3-epoxy-5-O-trityl-β-D-lyxo-pentofuranosyl)thymine