3-Pyridinecarbonitrile,6-formyl-1,2-dihydro-4-methyl-2-oxo-1-(2-propynyl)-(9CI)

Base Information

• Chemical Name: 3-Pyridinecarbonitrile,6-formyl-1,2-dihydro-4-methyl-2-oxo-1-(2-propynyl)-(9CI)
• CAS No.: 823235-06-9
• Molecular Formula: C₁₁H₈N₂O₂
• Molecular Weight: 200.197
• Mol file: 823235-06-9.mol

Synonyms:3-Pyridinecarbonitrile,6-formyl-1,2-dihydro-4-methyl-2-oxo-1-(2-propynyl)-(9CI)

Chemical Property of 3-Pyridinecarbonitrile,6-formyl-1,2-dihydro-4-methyl-2-oxo-1-(2-propynyl)-(9CI)

Chemical Property:

• PSA: 62.86000
• LogP: 0.47408

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Pyridinecarbonitrile,6-formyl-1,2-dihydro-4-methyl-2-oxo-1-(2-propynyl)-(9CI)

There total 2 articles about 3-Pyridinecarbonitrile,6-formyl-1,2-dihydro-4-methyl-2-oxo-1-(2-propynyl)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

6-dimethoxymethyl-4-methyl-2-oxo-1-propyn-2-ynyl-1,2-dihydropyridine-3-carbonitrile (823235-12-7) → 6-formyl-4-methyl-2-oxo-1-propyn-2-ynyl-1,2-dihydropyridine-3-carbonitrile (823235-06-9)

Guidance literature:

With hydrogenchloride; water; acetic acid; at 60 ℃; for 1h;

DOI:10.1021/ol0479848

Reference yield:

6-dimethoxymethyl-4-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile (823235-05-8) → 6-formyl-4-methyl-2-oxo-1-propyn-2-ynyl-1,2-dihydropyridine-3-carbonitrile (823235-06-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 86 percent / K₂CO₃; LiBr; TBAB / toluene; H₂O / 1 h / 100 °C

2: 95 percent / HCl; glacial AcOH; H₂O / 1 h / 60 °C

With hydrogenchloride; tetrabutylammomium bromide; water; potassium carbonate; acetic acid; lithium bromide; In water; toluene;

DOI:10.1021/ol0479848

upstream raw materials:

6-dimethoxymethyl-4-methyl-2-oxo-1-propyn-2-ynyl-1,2-dihydropyridine-3-carbonitrile

6-dimethoxymethyl-4-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile