3-Pyridinecarbonitrile,6-(dimethoxymethyl)-1,2-dihydro-4-methyl-2-oxo-(9CI)

Base Information

• Chemical Name: 3-Pyridinecarbonitrile,6-(dimethoxymethyl)-1,2-dihydro-4-methyl-2-oxo-(9CI)
• CAS No.: 823235-05-8
• Molecular Formula: C₁₀H₁₂N₂O₃
• Molecular Weight: 208.217
• Mol file: 823235-05-8.mol

Synonyms:3-Pyridinecarbonitrile,6-(dimethoxymethyl)-1,2-dihydro-4-methyl-2-oxo-(9CI)

Chemical Property of 3-Pyridinecarbonitrile,6-(dimethoxymethyl)-1,2-dihydro-4-methyl-2-oxo-(9CI)

Chemical Property:

• PSA: 75.11000
• LogP: 0.84638

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Pyridinecarbonitrile,6-(dimethoxymethyl)-1,2-dihydro-4-methyl-2-oxo-(9CI)

There total 1 articles about 3-Pyridinecarbonitrile,6-(dimethoxymethyl)-1,2-dihydro-4-methyl-2-oxo-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

N,N-dimethylacetamide dimethyl acetal (18871-66-4) + Pyruvic aldehyde dimethyl acetal (6342-56-9) + cyanoacetic acid amide (107-91-5) → 6-dimethoxymethyl-4-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile (823235-05-8)

Guidance literature:

N,N-dimethylacetamide dimethyl acetal; Pyruvic aldehyde dimethyl acetal; In N,N-dimethyl-formamide; at 80 ℃; for 3h;

cyanoacetic acid amide; With sodium methylate; In N,N-dimethyl-formamide; at 100 ℃; for 3h;

DOI:10.1021/ol0479848

Reference yield:

6-dimethoxymethyl-4-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile (823235-05-8) → 6-formyl-4-methyl-2-oxo-1-propyn-2-ynyl-1,2-dihydropyridine-3-carbonitrile (823235-06-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 86 percent / K₂CO₃; LiBr; TBAB / toluene; H₂O / 1 h / 100 °C

2: 95 percent / HCl; glacial AcOH; H₂O / 1 h / 60 °C

With hydrogenchloride; tetrabutylammomium bromide; water; potassium carbonate; acetic acid; lithium bromide; In water; toluene;

DOI:10.1021/ol0479848

upstream raw materials:

N,N-dimethylacetamide dimethyl acetal

Pyruvic aldehyde dimethyl acetal

cyanoacetic acid amide

Downstream raw materials:

6-formyl-4-methyl-2-oxo-1-propyn-2-ynyl-1,2-dihydropyridine-3-carbonitrile