3-Pyridinecarbonitrile,6-(dimethoxymethyl)-1,2-dihydro-4-methyl-2-oxo-(9CI)

Base Information

Chemical Name:3-Pyridinecarbonitrile,6-(dimethoxymethyl)-1,2-dihydro-4-methyl-2-oxo-(9CI)
CAS No.:823235-05-8
Molecular Formula:C₁₀H₁₂N₂O₃
Molecular Weight:208.217
Hs Code.:
Mol file:823235-05-8.mol

Synonyms:3-Pyridinecarbonitrile,6-(dimethoxymethyl)-1,2-dihydro-4-methyl-2-oxo-(9CI)

Suppliers and Price of 3-Pyridinecarbonitrile,6-(dimethoxymethyl)-1,2-dihydro-4-methyl-2-oxo-(9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-Pyridinecarbonitrile,6-(dimethoxymethyl)-1,2-dihydro-4-methyl-2-oxo-(9CI)

Chemical Property:

PSA：75.11000
LogP:0.84638

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 3-Pyridinecarbonitrile,6-(dimethoxymethyl)-1,2-dihydro-4-methyl-2-oxo-(9CI)

There total 1 articles about 3-Pyridinecarbonitrile,6-(dimethoxymethyl)-1,2-dihydro-4-methyl-2-oxo-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

: 18871-66-4
N,N-dimethylacetamide dimethyl acetal

: 6342-56-9
Pyruvic aldehyde dimethyl acetal

: 107-91-5
cyanoacetic acid amide

: 823235-05-8
6-dimethoxymethyl-4-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile

Guidance literature:: N,N-dimethylacetamide dimethyl acetal; Pyruvic aldehyde dimethyl acetal; In N,N-dimethyl-formamide; at 80 ℃; for 3h;

cyanoacetic acid amide; With sodium methylate; In N,N-dimethyl-formamide; at 100 ℃; for 3h;
DOI:10.1021/ol0479848

Reference yield:

: 823235-05-8
6-dimethoxymethyl-4-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile

: 823235-06-9
6-formyl-4-methyl-2-oxo-1-propyn-2-ynyl-1,2-dihydropyridine-3-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / K₂CO₃; LiBr; TBAB / toluene; H₂O / 1 h / 100 °C

2: 95 percent / HCl; glacial AcOH; H₂O / 1 h / 60 °C

With hydrogenchloride; tetrabutylammomium bromide; water; potassium carbonate; acetic acid; lithium bromide; In water; toluene;
DOI:10.1021/ol0479848