(R)-(4-fluorophenyl)(8-methyl-3-(2-phenylthiazol-4-yl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanone

Base Information

Chemical Name:(R)-(4-fluorophenyl)(8-methyl-3-(2-phenylthiazol-4-yl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanone
CAS No.:1338372-60-3
Molecular Formula:C₂₂H₁₈FN₅OS
Molecular Weight:419.482
Hs Code.:

Synonyms:(R)-(4-fluorophenyl)(8-methyl-3-(2-phenylthiazol-4-yl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanone

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Chemical Property of (R)-(4-fluorophenyl)(8-methyl-3-(2-phenylthiazol-4-yl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanone

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Technology Process of (R)-(4-fluorophenyl)(8-methyl-3-(2-phenylthiazol-4-yl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanone

There total 7 articles about (R)-(4-fluorophenyl)(8-methyl-3-(2-phenylthiazol-4-yl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1338375-70-4
(R)-4-(8-methyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-2-phenylthiazole hydrochloride

: 403-43-0
4-fluorobenzoyl chloride

: 1338372-60-3
(R)-(4-fluorophenyl)(8-methyl-3-(2-phenylthiazol-4-yl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanone

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: (R)-4-(8-methyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-2-phenylthiazole

: 403-43-0
4-fluorobenzoyl chloride

: 1338372-60-3
(R)-(4-fluorophenyl)(8-methyl-3-(2-phenylthiazol-4-yl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanone

Guidance literature:: (R)-4-(8-methyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-2-phenylthiazole; With 4-methyl-morpholine; In dichloromethane; at 0 - 20 ℃; for 0.5h; Inert atmosphere;

4-fluorobenzoyl chloride; In dichloromethane; at 0 - 20 ℃; for 0.166667h; Inert atmosphere;
DOI:10.1021/jm5017413

Reference yield:

: 1383146-20-0
(R)-4-(2,4-dimethoxybenzyl)-3-methylpiperazin-2-one

: 1338372-60-3
(R)-(4-fluorophenyl)(8-methyl-3-(2-phenylthiazol-4-yl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium carbonate / dichloromethane / 0.75 h / 15 - 20 °C / Inert atmosphere

2.1: methanol / 8 h / 60 - 70 °C / Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane / 0.25 h / 0 - 20 °C / Inert atmosphere

3.2: 0.5 h / Inert atmosphere

4.1: 4-methyl-morpholine / dichloromethane / 0.5 h / 0 - 20 °C / Inert atmosphere

4.2: 0.17 h / 0 - 20 °C / Inert atmosphere

With 4-methyl-morpholine; sodium carbonate; trifluoroacetic acid; In methanol; dichloromethane;
DOI:10.1021/jm5017413