7,8-dihydro-7-methyl-5-(4-methylphenyl)-8-oxo-1,7-naphthyridine-6-carboxylic acid

Base Information

Chemical Name:7,8-dihydro-7-methyl-5-(4-methylphenyl)-8-oxo-1,7-naphthyridine-6-carboxylic acid
CAS No.:170640-09-2
Molecular Formula:C₁₇H₁₄N₂O₃
Molecular Weight:294.31
Hs Code.:

Synonyms:7,8-dihydro-7-methyl-5-(4-methylphenyl)-8-oxo-1,7-naphthyridine-6-carboxylic acid

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Chemical Property of 7,8-dihydro-7-methyl-5-(4-methylphenyl)-8-oxo-1,7-naphthyridine-6-carboxylic acid

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Technology Process of 7,8-dihydro-7-methyl-5-(4-methylphenyl)-8-oxo-1,7-naphthyridine-6-carboxylic acid

There total 9 articles about 7,8-dihydro-7-methyl-5-(4-methylphenyl)-8-oxo-1,7-naphthyridine-6-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 168543-07-5
7,8-dihydro-7-methyl-5-(4-methylphenyl)-8-oxo-6-pyrido<3,4-b>pyridinecarboxaldehyde

: 170640-09-2
7,8-dihydro-7-methyl-5-(4-methylphenyl)-8-oxo-1,7-naphthyridine-6-carboxylic acid

Guidance literature:: With sodium hydroxide; potassium permanganate; In tert-butyl alcohol; for 0.666667h;
DOI:10.1021/jm00016a014

Reference yield: 78.0%

: 168542-78-7
7,8-dihydro-7-methyl-5-(4-methylphenyl)-8-oxo-6-pyrido<3,4-b>pyridinecarboxamide

: 170640-09-2
7,8-dihydro-7-methyl-5-(4-methylphenyl)-8-oxo-1,7-naphthyridine-6-carboxylic acid

Guidance literature:: With hydrogenchloride; acetic acid; sodium nitrite; for 15h; Ambient temperature;
DOI:10.1021/jm00016a014

Reference yield:

: 699-98-9
Pyridine-2,3-dicarboxylic anhydride

: 170640-09-2
7,8-dihydro-7-methyl-5-(4-methylphenyl)-8-oxo-1,7-naphthyridine-6-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 63 percent / AlCl₃ / 4 h / Heating

2: SOCl₂, DMF / tetrahydrofuran / 3.5 h / Heating

3: Et₃N / tetrahydrofuran / Heating

4: 56 percent / 1,8-diazabicyclo<5.4.0>undec-7-ene / toluene / 4 h / Heating

5: 96 percent / 1 N NaOH / ethanol / 0.67 h / Heating

6: 78 percent / AcOH, conc. HCl, NaNO₂ / 15 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; aluminium trichloride; thionyl chloride; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; N,N-dimethyl-formamide; sodium nitrite; In tetrahydrofuran; ethanol; toluene;
DOI:10.1021/jm00016a014