699-98-9

Basic information

• Product Name: 2,3-Pyridinedicarboxylic anhydride
• Synonyms: QUINOLINIC ANHYDRIDE;PYRIDINE-2,3-DICARBOXYLIC ACID ANHYDRIDE;PYRIDINE-2,3-DICARBOXYLIC ANHYDRIDE;FURO[3,4-B]PYRIDINE-5,7-DIONE;2,3-PYRIDINEDICARBOXYLIC ANHYDRIDE;2,3-PyridinedicarboxylicAcidAnhydride;Pyridinedicarboxylicanhydride;2,3-PYRIDINEDICARBOXYLIC ANHYDRIDE (QUINOLINIC ANHYDRIDE)
• CAS NO: 699-98-9
• Molecular Formula: C₇H₃NO₃
• Molecular Weight: 149.1
• EINECS: 211-834-1
• Product Categories: pyridine derivative;Aromatics;Heterocycles;Miscellaneous Reagents;Building Blocks;C7;Chemical Synthesis;Heterocyclic Building Blocks;Pyridines;Heterocycle-Pyridine series
• Mol File: 699-98-9.mol
• Article Data: 26

Chemical Properties

• Melting Point: 137-139 °C(lit.)
• Boiling Point: 270.14°C (rough estimate)
• Flash Point: 156.2 °C
• Appearance: white crystal powder
• Density: 1.4974 (rough estimate)
• Vapor Pressure: 0.000127mmHg at 25°C
• Refractive Index: 1.4835 (estimate)
• Storage Temp.: Room temperature.
• PKA: -2.24±0.20(Predicted)
• Water Solubility: Optimal solubility in water.
• Sensitive: Moisture Sensitive
• BRN: 125111
• CAS DataBase Reference: 2,3-Pyridinedicarboxylic anhydride(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-Pyridinedicarboxylic anhydride(699-98-9)
• EPA Substance Registry System: 2,3-Pyridinedicarboxylic anhydride(699-98-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-37/39
• WGK Germany: 3
• F: 10-21
• TSCA: Yes
• Hazardous Substances Data: 699-98-9(Hazardous Substances Data)

Usage

Chemical Properties

white crystal powde

Uses

Quinolinic Anhydride (cas# 699-98-9) is a compound useful in organic synthesis.

InChI:InChI=1/C7H3NO3/c9-6-4-2-1-3-8-5(4)7(10)11-6/h1-3H

Upstream product

• 89-00-9 Pyridine-2,3-dicarboxylic acid 
• 89-01-0 2,3-dicarboxypyrazine 
• 10026-13-8 phosphorus pentachloride 
• 108-24-7 acetic anhydride 

Downstream Products

• 70-19-9 Tetrahydrofurfuryl nicotinate 
• 4664-00-0 2,3-pyridinedicarboximide 
• 24195-07-1 pyridine-2,3-dicarboxylic acid 2-methyl ester 
• 24195-02-6 pyridine-2,3-dicarboxylic acid 3-methyl ester 
• 100872-65-9 2-[[(phenylmethyl)amino]carbonyl]-3-pyridinecarboxylic acid 
• 846042-53-3 pyridine-2,3-dicarboxylic acid mono-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-ylamide) 
• 100616-13-5 2-cyclohexylcarbamoyl-nicotinic acid 
• 846601-53-4 2-diphenylcarbamoyl-nicotinic acid 
• 59-26-7 N,N-diethylnicotinamide 
• 108078-33-7 2-(N-phenylcarbamoyl)pyridine-3-carboxylic acid 
• 3712-11-6 6,9-dihydroxybenzoquinoline-5,10-quinone 
• 17431-87-7 pyridine-2,3-dicarboxylic acid bis-(N'-phenyl-hydrazide) 
• 6789-51-1 6-methyl-5H-pyrrolo[3,4-b]pyridine-5,7(6H)-dione 

Relevant articles and documents

SYNTHESIS OF A SICKLE CELL DISEASE AGENT AND INTERMEDIATES THEREOF

New processes for preparing 2-hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5- yl)pyridin-3-yl)methoxy)benzaldehyde, an agent developed for the treatment of sickle cell disease, and intermediates thereof, are provided herein.

Synthesis method of imazapyracid

The invention relates to a synthesis method of imazapyracid, relates to a preparation method of a compound, and in particular, relates to a production and synthesis method of imazapyracid; the methodis characterized by comprising the steps: taking quinolinic acid as a raw material and reacting with acetic anhydride to generate 2,3-pyridine dicarboxylic anhydride; and under a low-temperature condition, continuously reacting with alcohol to generate a compound represented by a structural formula (I), carrying out a ring closing reaction with 2-amino-2,3-dimethylbutyramide under an alkaline condition, extracting to adjust the pH value, and thus obtaining the imazapyracid product. The method has the advantages that a novel method for obtaining imazapyracid is provided, the route reaction speed is high, the product purity is extremely high, the yield is high, the reaction conditions are mild, isomers are avoided, catalysts are not needed, three wastes are few, the synthesis process is extensive, the reaction conditions are optimized, the reaction equipment cost is reduced, generated products are easy to separate, and the production process is simplified.

Preparation method of moxifloxacin important intermediate (by machine translation)

The invention discloses a preparation method, of an important intermediate of moxifloxacin. 2, 3 - Picolinic acid and acetic anhydride are charged first to the reaction kettle, stirred, and stirred to prepare a reaction feed liquid; a first reaction liquid is pumped into a continuous acid removal system filled with an acid remover, and then the reaction liquid is pumped into second reaction kettle; the second reaction kettle is used for stirring reaction; and after the reaction is finished, the reaction mixture liquid is stirred by 2nd. Concentration, a significant intermediate, namely compound 6 - benzyl - 555H-pyrrolo [3, 4 - b] pyridine -5, 7 - (6H) - diketone, is obtained under reduced pressure. The method effectively improves the conversion, greatly improves the yield, enhances the operability, realizes low energy consumption, and can realize the purpose. (by machine translation)