1-((S)-1-((((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(methyl)amino)pentan-3-yl)-3-(4-(tert-butyl)phenyl)urea

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Chemical Name:1-((S)-1-((((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(methyl)amino)pentan-3-yl)-3-(4-(tert-butyl)phenyl)urea
CAS No.:1381761-94-9
Molecular Formula:C₂₇H₄₀N₈O₄
Molecular Weight:540.666
Hs Code.:

Synonyms:1-((S)-1-((((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(methyl)amino)pentan-3-yl)-3-(4-(tert-butyl)phenyl)urea

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Chemical Property of 1-((S)-1-((((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(methyl)amino)pentan-3-yl)-3-(4-(tert-butyl)phenyl)urea

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Technology Process of 1-((S)-1-((((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(methyl)amino)pentan-3-yl)-3-(4-(tert-butyl)phenyl)urea

There total 4 articles about 1-((S)-1-((((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(methyl)amino)pentan-3-yl)-3-(4-(tert-butyl)phenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1381761-93-8
1-((S)-1-((((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)(methyl)amino)pentan-3-yl)-3-(4-(tert-butyl)phenyl)urea

: 1381761-94-9
1-((S)-1-((((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(methyl)amino)pentan-3-yl)-3-(4-(tert-butyl)phenyl)urea

Guidance literature:: 1-((S)-1-((((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)(methyl)amino)pentan-3-yl)-3-(4-(tert-butyl)phenyl)urea; With hydrogenchloride; In methanol; at 30 ℃; for 1.5h;

With potassium carbonate; In methanol; for 0.0833333h; pH=8;

Reference yield:

: 1086106-57-1
(S)-3-amino-pentanoic acid methyl ester

: 1381761-94-9
1-((S)-1-((((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(methyl)amino)pentan-3-yl)-3-(4-(tert-butyl)phenyl)urea

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / dichloromethane / 2 h / 0 - 20 °C

2.1: lithium borohydride / tetrahydrofuran / 16 h / 0 - 20 °C

3.1: 2-iodoxybenzoic acid / ethyl acetate / 1.5 h / Reflux; Inert atmosphere

4.1: 1,2-dichloro-ethane / 0.5 h / 20 °C

4.2: 15 h / 20 °C

5.1: hydrogenchloride / methanol / 1.5 h / 30 °C

5.2: 0.08 h / pH 8

With hydrogenchloride; lithium borohydride; 2-iodoxybenzoic acid; triethylamine; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; 1,2-dichloro-ethane;

Reference yield:

: 14389-77-6
(3S)-3-aminopentanoic acid

: 1381761-94-9
1-((S)-1-((((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(methyl)amino)pentan-3-yl)-3-(4-(tert-butyl)phenyl)urea

Guidance literature:: Multi-step reaction with 6 steps

1.1: thionyl chloride / 1 h / -10 °C

1.2: 15 h / 20 °C

2.1: triethylamine / dichloromethane / 2 h / 0 - 20 °C

3.1: lithium borohydride / tetrahydrofuran / 16 h / 0 - 20 °C

4.1: 2-iodoxybenzoic acid / ethyl acetate / 1.5 h / Reflux; Inert atmosphere

5.1: 1,2-dichloro-ethane / 0.5 h / 20 °C

5.2: 15 h / 20 °C

6.1: hydrogenchloride / methanol / 1.5 h / 30 °C

6.2: 0.08 h / pH 8

With hydrogenchloride; lithium borohydride; thionyl chloride; 2-iodoxybenzoic acid; triethylamine; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; 1,2-dichloro-ethane;