1,4-dihydro-2,6-dimethyl-4-(3-isothiocyanatophenyl)-3,5-pyrazinedicarboxylic acid, dimethyl ester

Base Information

Chemical Name:1,4-dihydro-2,6-dimethyl-4-(3-isothiocyanatophenyl)-3,5-pyrazinedicarboxylic acid, dimethyl ester
CAS No.:314241-27-5
Molecular Formula:C₁₇H₁₇N₃O₄S
Molecular Weight:359.406
Hs Code.:

Synonyms:1,4-dihydro-2,6-dimethyl-4-(3-isothiocyanatophenyl)-3,5-pyrazinedicarboxylic acid, dimethyl ester

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Chemical Property of 1,4-dihydro-2,6-dimethyl-4-(3-isothiocyanatophenyl)-3,5-pyrazinedicarboxylic acid, dimethyl ester

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Technology Process of 1,4-dihydro-2,6-dimethyl-4-(3-isothiocyanatophenyl)-3,5-pyrazinedicarboxylic acid, dimethyl ester

There total 5 articles about 1,4-dihydro-2,6-dimethyl-4-(3-isothiocyanatophenyl)-3,5-pyrazinedicarboxylic acid, dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 6160-65-2
1,1'-Thiocarbonyldiimidazole

: 314241-26-4
4-(3-aminophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyrazinedicarboxylic acid, dimethyl ester

: 314241-27-5
1,4-dihydro-2,6-dimethyl-4-(3-isothiocyanatophenyl)-3,5-pyrazinedicarboxylic acid, dimethyl ester

Guidance literature:: In N,N-dimethyl-formamide; for 0.5h;
DOI:10.1016/S0960-894X(01)00765-X

Reference yield:

: 24762-04-7
2-Diazo-3-oxo-butyric acid methyl ester

: 314241-27-5
1,4-dihydro-2,6-dimethyl-4-(3-isothiocyanatophenyl)-3,5-pyrazinedicarboxylic acid, dimethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 26.3 percent / Rh₂(OAc)4 / benzene / Heating

2: 69 percent / ammonium acetate / 2-methyl-propan-2-ol / 0.5 h / Heating

3: 88 percent / Fe; aq. HCl / methanol / 3.5 h / Heating

4: 87 percent / dimethylformamide / 0.5 h

With ammonium acetate; hydrogenchloride; dirhodium tetraacetate; iron; In methanol; N,N-dimethyl-formamide; tert-butyl alcohol; benzene;
DOI:10.1016/S0960-894X(01)00765-X

Reference yield:

: 99-09-2
3-nitro-aniline

: 314241-27-5
1,4-dihydro-2,6-dimethyl-4-(3-isothiocyanatophenyl)-3,5-pyrazinedicarboxylic acid, dimethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 26.3 percent / Rh₂(OAc)4 / benzene / Heating

2: 69 percent / ammonium acetate / 2-methyl-propan-2-ol / 0.5 h / Heating

3: 88 percent / Fe; aq. HCl / methanol / 3.5 h / Heating

4: 87 percent / dimethylformamide / 0.5 h

With ammonium acetate; hydrogenchloride; dirhodium tetraacetate; iron; In methanol; N,N-dimethyl-formamide; tert-butyl alcohol; benzene;
DOI:10.1016/S0960-894X(01)00765-X