(R)-N-methyl-N-{3-phenyl-3-[4-trifluoromethyl]phenoxylpropyl}acetamide

Base Information

Chemical Name:(R)-N-methyl-N-{3-phenyl-3-[4-trifluoromethyl]phenoxylpropyl}acetamide
CAS No.:1620141-91-4
Molecular Formula:C₁₉H₂₀F₃NO₂
Molecular Weight:351.369
Hs Code.:

Synonyms:(R)-N-methyl-N-{3-phenyl-3-[4-trifluoromethyl]phenoxylpropyl}acetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-N-methyl-N-{3-phenyl-3-[4-trifluoromethyl]phenoxylpropyl}acetamide

Chemical Property:

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Technology Process of (R)-N-methyl-N-{3-phenyl-3-[4-trifluoromethyl]phenoxylpropyl}acetamide

There total 4 articles about (R)-N-methyl-N-{3-phenyl-3-[4-trifluoromethyl]phenoxylpropyl}acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 108-24-7
acetic anhydride

: 54910-89-3,57226-07-0,100568-02-3,100568-03-4
(R)-fluoxetine

: 1620141-91-4
(R)-N-methyl-N-{3-phenyl-3-[4-trifluoromethyl]phenoxylpropyl}acetamide

Guidance literature:: With pyridine; In dichloromethane;
DOI:10.1039/c4ob01142b

Reference yield:

: 104-55-2
3-phenyl-propenal

: 1620141-91-4
(R)-N-methyl-N-{3-phenyl-3-[4-trifluoromethyl]phenoxylpropyl}acetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrahydrofuran / 6 h / 20 °C / Molecular sieve

2.1: copper(l) chloride; (R)-(+)-2,2'-bis[bis(3,5-dimethylphenyl)phosphino]-1,1'-binaphthyl; sodium t-butanolate / methanol / 15 h / 20 °C / Schlenk technique; Inert atmosphere

2.2: 1.5 h / 20 °C / Schlenk technique; Inert atmosphere

3.1: sodium hydride / N,N-dimethyl acetamide / 0.5 h / 70 °C

3.2: 3 h / 100 °C

4.1: pyridine / dichloromethane

With pyridine; (R)-(+)-2,2'-bis[bis(3,5-dimethylphenyl)phosphino]-1,1'-binaphthyl; sodium hydride; copper(l) chloride; sodium t-butanolate; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl acetamide;
DOI:10.1039/c4ob01142b

Reference yield:

: 108606-85-5
N-[(3-phenylprop-2-en)methylene]-α-phenylbenzenemethanamine

: 1620141-91-4
(R)-N-methyl-N-{3-phenyl-3-[4-trifluoromethyl]phenoxylpropyl}acetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: copper(l) chloride; (R)-(+)-2,2'-bis[bis(3,5-dimethylphenyl)phosphino]-1,1'-binaphthyl; sodium t-butanolate / methanol / 15 h / 20 °C / Schlenk technique; Inert atmosphere

1.2: 1.5 h / 20 °C / Schlenk technique; Inert atmosphere

2.1: sodium hydride / N,N-dimethyl acetamide / 0.5 h / 70 °C

2.2: 3 h / 100 °C

3.1: pyridine / dichloromethane

With pyridine; (R)-(+)-2,2'-bis[bis(3,5-dimethylphenyl)phosphino]-1,1'-binaphthyl; sodium hydride; copper(l) chloride; sodium t-butanolate; In methanol; dichloromethane; N,N-dimethyl acetamide;
DOI:10.1039/c4ob01142b