tert-butyl 3-(2,6-difluoro-4-(1-(methylsulfonyl)piperidin-4-yl)phenoxy)azetidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 3-(2,6-difluoro-4-(1-(methylsulfonyl)piperidin-4-yl)phenoxy)azetidine-1-carboxylate
CAS No.:1287686-18-3
Molecular Formula:C₂₀H₂₈F₂N₂O₅S
Molecular Weight:446.516
Hs Code.:

Synonyms:tert-butyl 3-(2,6-difluoro-4-(1-(methylsulfonyl)piperidin-4-yl)phenoxy)azetidine-1-carboxylate

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Chemical Property of tert-butyl 3-(2,6-difluoro-4-(1-(methylsulfonyl)piperidin-4-yl)phenoxy)azetidine-1-carboxylate

Chemical Property:

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Technology Process of tert-butyl 3-(2,6-difluoro-4-(1-(methylsulfonyl)piperidin-4-yl)phenoxy)azetidine-1-carboxylate

There total 7 articles about tert-butyl 3-(2,6-difluoro-4-(1-(methylsulfonyl)piperidin-4-yl)phenoxy)azetidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1287686-08-1
2,6-difluoro-4-(1-(methylsulfonyl)piperidin-4-yl)phenol

: 141699-58-3
3-methanesulfonyloxy-azetidine-1-carboxylic acid tert-butyl ester

: 1287686-18-3
tert-butyl 3-(2,6-difluoro-4-(1-(methylsulfonyl)piperidin-4-yl)phenoxy)azetidine-1-carboxylate

Guidance literature:: 2,6-difluoro-4-(1-(methylsulfonyl)piperidin-4-yl)phenol; With potassium tert-butylate; In dimethyl sulfoxide; at 20 ℃; for 0.333333h;

3-methanesulfonyloxy-azetidine-1-carboxylic acid tert-butyl ester; In dimethyl sulfoxide; at 100 ℃; for 72h;

Reference yield:

: 104197-14-0
5-bromo-1,3-difluoro-2-methoxy-benzene

: 1287686-18-3
tert-butyl 3-(2,6-difluoro-4-(1-(methylsulfonyl)piperidin-4-yl)phenoxy)azetidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 0.25 h / 150 °C / Microwave irradiation; Sealed tube

2.1: hydrogen; trifluoroacetic acid; acetic acid / platinum(IV) oxide / 7 h

3.1: triethylamine / dichloromethane / 0.5 h / 0 - 23 °C

4.1: boron tribromide / dichloromethane / 1.5 h / 0 - 20 °C

5.1: potassium tert-butylate / dimethyl sulfoxide / 0.33 h / 20 °C

5.2: 72 h / 100 °C

With potassium tert-butylate; hydrogen; boron tribromide; caesium carbonate; acetic acid; triethylamine; trifluoroacetic acid; platinum(IV) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 1692-15-5
4-pyridylboronic acid

: 1287686-18-3
tert-butyl 3-(2,6-difluoro-4-(1-(methylsulfonyl)piperidin-4-yl)phenoxy)azetidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 0.25 h / 150 °C / Microwave irradiation; Sealed tube

2.1: hydrogen; trifluoroacetic acid; acetic acid / platinum(IV) oxide / 7 h

3.1: triethylamine / dichloromethane / 0.5 h / 0 - 23 °C

4.1: boron tribromide / dichloromethane / 1.5 h / 0 - 20 °C

5.1: potassium tert-butylate / dimethyl sulfoxide / 0.33 h / 20 °C

5.2: 72 h / 100 °C

With potassium tert-butylate; hydrogen; boron tribromide; caesium carbonate; acetic acid; triethylamine; trifluoroacetic acid; platinum(IV) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;