O-(2R,3S)-3-[(S)-2-oxo-4-phenyloxazolidin-3-ylcarbonyl]heptan-2-yl O-phenyl carbonothioate

Base Information

Chemical Name:O-(2R,3S)-3-[(S)-2-oxo-4-phenyloxazolidin-3-ylcarbonyl]heptan-2-yl O-phenyl carbonothioate
CAS No.:1418183-64-8
Molecular Formula:C₂₄H₂₇NO₅S
Molecular Weight:441.548
Hs Code.:

Synonyms:O-(2R,3S)-3-[(S)-2-oxo-4-phenyloxazolidin-3-ylcarbonyl]heptan-2-yl O-phenyl carbonothioate

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Chemical Property of O-(2R,3S)-3-[(S)-2-oxo-4-phenyloxazolidin-3-ylcarbonyl]heptan-2-yl O-phenyl carbonothioate

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Technology Process of O-(2R,3S)-3-[(S)-2-oxo-4-phenyloxazolidin-3-ylcarbonyl]heptan-2-yl O-phenyl carbonothioate

There total 4 articles about O-(2R,3S)-3-[(S)-2-oxo-4-phenyloxazolidin-3-ylcarbonyl]heptan-2-yl O-phenyl carbonothioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1418183-63-7
(S)-3-{(S)-2-[(R)-1-hydroxyethyl]hexanoyl}-4-phenyloxazolidin-2-one

: 1005-56-7
phenylcarbonochloridothioate

: 1418183-64-8
O-(2R,3S)-3-[(S)-2-oxo-4-phenyloxazolidin-3-ylcarbonyl]heptan-2-yl O-phenyl carbonothioate

Guidance literature:: With dmap; In dichloromethane; at 20 ℃; for 1h; enantioselective reaction; Inert atmosphere;
DOI:10.1055/s-0032-1316776

Reference yield:

: 99395-88-7,7480-32-2
(S)-4-phenyl-2-oxazolidinone

: 1418183-64-8
O-(2R,3S)-3-[(S)-2-oxo-4-phenyloxazolidin-3-ylcarbonyl]heptan-2-yl O-phenyl carbonothioate

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; dmap / dichloromethane / 20 °C / Inert atmosphere; Cooling with ice

2.1: titanium tetrachloride; sparteine / dichloromethane / 0.33 h / Inert atmosphere; Cooling with ice

2.2: -78 °C / Inert atmosphere; Cooling with acetone-dry ice

2.3: 1 h / 0 °C / Inert atmosphere

3.1: dmap / dichloromethane / 1 h / 20 °C / Inert atmosphere

With dmap; titanium tetrachloride; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; sparteine; In dichloromethane;
DOI:10.1055/s-0032-1316776

Reference yield:

: 142-62-1
hexanoic acid

: 1418183-64-8
O-(2R,3S)-3-[(S)-2-oxo-4-phenyloxazolidin-3-ylcarbonyl]heptan-2-yl O-phenyl carbonothioate

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; dmap / dichloromethane / 20 °C / Inert atmosphere; Cooling with ice

2.1: titanium tetrachloride; sparteine / dichloromethane / 0.33 h / Inert atmosphere; Cooling with ice

2.2: -78 °C / Inert atmosphere; Cooling with acetone-dry ice

2.3: 1 h / 0 °C / Inert atmosphere

3.1: dmap / dichloromethane / 1 h / 20 °C / Inert atmosphere

With dmap; titanium tetrachloride; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; sparteine; In dichloromethane;
DOI:10.1055/s-0032-1316776