{9-[(2R,3R,4R,5R)-4-(2-{2-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-ethoxy}-ethoxy)-3-trityloxy-5-trityloxymethyl-tetrahydro-furan-2-yl]-9H-purin-6-yl}-trityl-amine

Base Information

Chemical Name:{9-[(2R,3R,4R,5R)-4-(2-{2-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-ethoxy}-ethoxy)-3-trityloxy-5-trityloxymethyl-tetrahydro-furan-2-yl]-9H-purin-6-yl}-trityl-amine
CAS No.:191853-38-0
Molecular Formula:C₇₉H₈₁N₅O₆Si
Molecular Weight:1224.63
Hs Code.:

{9-[(2R,3R,4R,5R)-4-(2-{2-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-ethoxy}-ethoxy)-3-trityloxy-5-trityloxymethyl-tetrahydro-furan-2-yl]-9H-purin-6-yl}-trityl-amine

Synonyms:{9-[(2R,3R,4R,5R)-4-(2-{2-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-ethoxy}-ethoxy)-3-trityloxy-5-trityloxymethyl-tetrahydro-furan-2-yl]-9H-purin-6-yl}-trityl-amine

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Chemical Property of {9-[(2R,3R,4R,5R)-4-(2-{2-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-ethoxy}-ethoxy)-3-trityloxy-5-trityloxymethyl-tetrahydro-furan-2-yl]-9H-purin-6-yl}-trityl-amine

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Technology Process of {9-[(2R,3R,4R,5R)-4-(2-{2-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-ethoxy}-ethoxy)-3-trityloxy-5-trityloxymethyl-tetrahydro-furan-2-yl]-9H-purin-6-yl}-trityl-amine

There total 1 articles about {9-[(2R,3R,4R,5R)-4-(2-{2-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-ethoxy}-ethoxy)-3-trityloxy-5-trityloxymethyl-tetrahydro-furan-2-yl]-9H-purin-6-yl}-trityl-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: [2-(2-iodoethoxy)ethoxy]dimethyl(1,1,2-trimethylpropyl)silane

: 31085-56-0
(2R,3R,4R,5R)-5-(6-(tritylamino)-9H-purin-9-yl)-4-(trityloxy)-2-((trityloxy)methyl)tetrahydrofuran-3-ol

: 191853-38-0
{9-[(2R,3R,4R,5R)-4-(2-{2-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-ethoxy}-ethoxy)-3-trityloxy-5-trityloxymethyl-tetrahydro-furan-2-yl]-9H-purin-6-yl}-trityl-amine

Guidance literature:: With sodium hydride; In acetonitrile; for 4h; Ambient temperature;
DOI:10.1002/hlca.19970800313

Reference yield: 91.0%

: 191853-38-0
{9-[(2R,3R,4R,5R)-4-(2-{2-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-ethoxy}-ethoxy)-3-trityloxy-5-trityloxymethyl-tetrahydro-furan-2-yl]-9H-purin-6-yl}-trityl-amine

: 191853-41-5
2-(2-{(2R,3R,4R,5R)-5-[6-(Trityl-amino)-purin-9-yl]-4-trityloxy-2-trityloxymethyl-tetrahydro-furan-3-yloxy}-ethoxy)-ethanol

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; Ambient temperature;
DOI:10.1002/hlca.19970800313

Reference yield:

: 191853-38-0
{9-[(2R,3R,4R,5R)-4-(2-{2-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-ethoxy}-ethoxy)-3-trityloxy-5-trityloxymethyl-tetrahydro-furan-2-yl]-9H-purin-6-yl}-trityl-amine

: 191853-55-1
4-Oxo-pentanoic acid 2-[2-((2R,3S,4R,5R)-4-hydroxy-2-hydroxymethyl-5-{6-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-purin-9-yl}-tetrahydro-furan-3-yloxy)-ethoxy]-ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 91 percent / Bu₄NF*3H₂O / tetrahydrofuran / Ambient temperature

2: 92 percent / EDC*HCl, DMAP / CH₂Cl₂ / 3 h / Ambient temperature

3: 88 percent / 80percent AcOH / H₂O / 0.5 h / 100 °C

4: (NH₂₄)SO₄ / dioxane / 3 h / Heating

5: CH₂Cl₂

6: 80percent AcOH / H₂O / 1 h

With dmap; (NH₂₄)SO₄; tetrabutyl ammonium fluoride; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;
DOI:10.1002/hlca.19970800313