2-(2-{(2R,3R,4R,5R)-5-[6-(Trityl-amino)-purin-9-yl]-4-trityloxy-2-trityloxymethyl-tetrahydro-furan-3-yloxy}-ethoxy)-ethanol

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Chemical Name:2-(2-{(2R,3R,4R,5R)-5-[6-(Trityl-amino)-purin-9-yl]-4-trityloxy-2-trityloxymethyl-tetrahydro-furan-3-yloxy}-ethoxy)-ethanol
CAS No.:191853-41-5
Molecular Formula:C₇₁H₆₃N₅O₆
Molecular Weight:1082.31
Hs Code.:

Synonyms:2-(2-{(2R,3R,4R,5R)-5-[6-(Trityl-amino)-purin-9-yl]-4-trityloxy-2-trityloxymethyl-tetrahydro-furan-3-yloxy}-ethoxy)-ethanol

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Chemical Property of 2-(2-{(2R,3R,4R,5R)-5-[6-(Trityl-amino)-purin-9-yl]-4-trityloxy-2-trityloxymethyl-tetrahydro-furan-3-yloxy}-ethoxy)-ethanol

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Technology Process of 2-(2-{(2R,3R,4R,5R)-5-[6-(Trityl-amino)-purin-9-yl]-4-trityloxy-2-trityloxymethyl-tetrahydro-furan-3-yloxy}-ethoxy)-ethanol

There total 1 articles about 2-(2-{(2R,3R,4R,5R)-5-[6-(Trityl-amino)-purin-9-yl]-4-trityloxy-2-trityloxymethyl-tetrahydro-furan-3-yloxy}-ethoxy)-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 191853-38-0
{9-[(2R,3R,4R,5R)-4-(2-{2-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-ethoxy}-ethoxy)-3-trityloxy-5-trityloxymethyl-tetrahydro-furan-2-yl]-9H-purin-6-yl}-trityl-amine

: 191853-41-5
2-(2-{(2R,3R,4R,5R)-5-[6-(Trityl-amino)-purin-9-yl]-4-trityloxy-2-trityloxymethyl-tetrahydro-furan-3-yloxy}-ethoxy)-ethanol

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; Ambient temperature;
DOI:10.1002/hlca.19970800313

Reference yield: 92.0%

: 123-76-2
levulinic acid

: 191853-41-5
2-(2-{(2R,3R,4R,5R)-5-[6-(Trityl-amino)-purin-9-yl]-4-trityloxy-2-trityloxymethyl-tetrahydro-furan-3-yloxy}-ethoxy)-ethanol

: 191853-46-0
4-Oxo-pentanoic acid 2-(2-{(2R,3R,4R,5R)-5-[6-(trityl-amino)-purin-9-yl]-4-trityloxy-2-trityloxymethyl-tetrahydro-furan-3-yloxy}-ethoxy)-ethyl ester

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; for 3h; Ambient temperature;
DOI:10.1002/hlca.19970800313

Reference yield:

: 191853-41-5
2-(2-{(2R,3R,4R,5R)-5-[6-(Trityl-amino)-purin-9-yl]-4-trityloxy-2-trityloxymethyl-tetrahydro-furan-3-yloxy}-ethoxy)-ethanol

: 191853-67-5
4-Oxo-pentanoic acid 2-(2-{(2R,3R,4R,5R)-2-hydroxymethyl-5-{6-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-purin-9-yl}-4-[2-(4-nitro-phenyl)-ethoxycarbonyloxy]-tetrahydro-furan-3-yloxy}-ethoxy)-ethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 92 percent / EDC*HCl, DMAP / CH₂Cl₂ / 3 h / Ambient temperature

2: 88 percent / 80percent AcOH / H₂O / 0.5 h / 100 °C

3: (NH₂₄)SO₄ / dioxane / 3 h / Heating

4: CH₂Cl₂

5: 80percent AcOH / H₂O / 1 h

6: 73 percent / pyridine / 24 h / Ambient temperature

7: 91 percent / DMAP / CH₂Cl₂ / Ambient temperature

8: 83 percent / 2percent TsOH / methanol; CHCl₃ / 0.25 h / Ambient temperature

With pyridine; dmap; (NH₂₄)SO₄; toluene-4-sulfonic acid; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; methanol; dichloromethane; chloroform; water;
DOI:10.1002/hlca.19970800313