N-(1-benzyl-3-ethyl-1H-indazol-4-yl)-7-(2-methoxyethoxy)imidazo[1,2-a]pyridine-3-carboxamide

Base Information

Chemical Name:N-(1-benzyl-3-ethyl-1H-indazol-4-yl)-7-(2-methoxyethoxy)imidazo[1,2-a]pyridine-3-carboxamide
CAS No.:1313407-30-5
Molecular Formula:C₂₇H₂₇N₅O₃
Molecular Weight:469.543
Hs Code.:

Synonyms:N-(1-benzyl-3-ethyl-1H-indazol-4-yl)-7-(2-methoxyethoxy)imidazo[1,2-a]pyridine-3-carboxamide

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Chemical Property of N-(1-benzyl-3-ethyl-1H-indazol-4-yl)-7-(2-methoxyethoxy)imidazo[1,2-a]pyridine-3-carboxamide

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Technology Process of N-(1-benzyl-3-ethyl-1H-indazol-4-yl)-7-(2-methoxyethoxy)imidazo[1,2-a]pyridine-3-carboxamide

There total 9 articles about N-(1-benzyl-3-ethyl-1H-indazol-4-yl)-7-(2-methoxyethoxy)imidazo[1,2-a]pyridine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1067914-88-8
7-(2-methoxyethoxy)imidazo[1,2-a]pyridine-3-carboxylic acid

: 1313409-06-1
1-benzyl-3-ethyl-1H-indazol-4-amine

: 1313407-30-5
N-(1-benzyl-3-ethyl-1H-indazol-4-yl)-7-(2-methoxyethoxy)imidazo[1,2-a]pyridine-3-carboxamide

Guidance literature:: 7-(2-methoxyethoxy)imidazo[1,2-a]pyridine-3-carboxylic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 5 ℃; for 0.166667h; sealed vial;

1-benzyl-3-ethyl-1H-indazol-4-amine; With triethylamine; In dichloromethane; at 20 ℃;

Reference yield:

: 2942-40-7
nitro-4 indazole

: 1313407-30-5
N-(1-benzyl-3-ethyl-1H-indazol-4-yl)-7-(2-methoxyethoxy)imidazo[1,2-a]pyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: iodine; potassium hydroxide / N,N-dimethyl-formamide / 38 h / 5 - 25 °C / Inert atmosphere

2.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 25 °C / Inert atmosphere

3.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; hexane / 2 h / Inert atmosphere; Reflux

4.1: iron; ammonium chloride / ethanol; water / 1 h / 85 °C

4.2: 0.25 h / 85 °C

5.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0.17 h / 5 °C / sealed vial

5.2: 20 °C

With oxalyl dichloride; iodine; iron; potassium carbonate; ammonium chloride; potassium hydroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; N,N-dimethyl-formamide; In 1,4-dioxane; ethanol; hexane; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1067914-32-2
2-chloro-4-(2-methoxyethoxy)pyridine

: 1313407-30-5
N-(1-benzyl-3-ethyl-1H-indazol-4-yl)-7-(2-methoxyethoxy)imidazo[1,2-a]pyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium hexamethyldisilazane / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / tetrahydrofuran / 0 - 65 °C / Inert atmosphere

1.2: 0.25 h / 30 °C

2.1: ethanol; benzene / 4 h / 60 °C / Inert atmosphere

3.1: lithium hydroxide monohydrate; water / tetrahydrofuran; ethanol / 22 h / 40 °C

3.2: pH 3

4.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0.17 h / 5 °C / sealed vial

4.2: 20 °C

With oxalyl dichloride; lithium hydroxide monohydrate; water; lithium hexamethyldisilazane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; N,N-dimethyl-formamide; XPhos; In tetrahydrofuran; ethanol; dichloromethane; benzene;