4-[4-(4-methoxyphenoxy)-3-nitrophenyl]-1,2-dimethyl-5-nitro-1H-imidazole

Base Information

Chemical Name:4-[4-(4-methoxyphenoxy)-3-nitrophenyl]-1,2-dimethyl-5-nitro-1H-imidazole
CAS No.:1400916-24-6
Molecular Formula:C₁₈H₁₆N₄O₆
Molecular Weight:384.348
Hs Code.:

Synonyms:4-[4-(4-methoxyphenoxy)-3-nitrophenyl]-1,2-dimethyl-5-nitro-1H-imidazole

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Chemical Property of 4-[4-(4-methoxyphenoxy)-3-nitrophenyl]-1,2-dimethyl-5-nitro-1H-imidazole

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Technology Process of 4-[4-(4-methoxyphenoxy)-3-nitrophenyl]-1,2-dimethyl-5-nitro-1H-imidazole

There total 4 articles about 4-[4-(4-methoxyphenoxy)-3-nitrophenyl]-1,2-dimethyl-5-nitro-1H-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1400916-23-5
4-(4-fluoro-3-nitrophenyl)-1,2-dimethyl-5-nitro-1H-imidazole

: 5720-07-0
4-methoxyphenylboronic acid

: 1400916-24-6
4-[4-(4-methoxyphenoxy)-3-nitrophenyl]-1,2-dimethyl-5-nitro-1H-imidazole

: 1400916-30-4
4-(1,2-dimethyl-5-nitro-1H-imidazol-4-yl)-2-nitrophenol

Guidance literature:: With 4a,9a-dihydro-9,9-dimethyl-4,5-bis(diphenylphosphino)-xanthene; tetrabutylammomium bromide; palladium diacetate; caesium carbonate; In 1,2-dimethoxyethane; at 70 ℃; for 48h; Inert atmosphere;
DOI:10.1016/j.tetlet.2012.07.107

Reference yield:

: 1197836-48-8
4-(4-fluorophenyl)-1,2-dimethyl-5-nitro-1H-imidazole

: 1400916-24-6
4-[4-(4-methoxyphenoxy)-3-nitrophenyl]-1,2-dimethyl-5-nitro-1H-imidazole

Guidance literature:: Multi-step reaction with 2 steps

1: nitric acid; sulfuric acid / 20 °C

2: 4a,9a-dihydro-9,9-dimethyl-4,5-bis(diphenylphosphino)-xanthene; caesium carbonate; tetrabutylammomium bromide; palladium diacetate / 1,2-dimethoxyethane / 48 h / 70 °C / Inert atmosphere

With 4a,9a-dihydro-9,9-dimethyl-4,5-bis(diphenylphosphino)-xanthene; sulfuric acid; tetrabutylammomium bromide; nitric acid; palladium diacetate; caesium carbonate; In 1,2-dimethoxyethane; 2: |Suzuki-Miyaura Coupling;
DOI:10.1016/j.tetlet.2012.07.107

Reference yield:

: 1400916-23-5
4-(4-fluoro-3-nitrophenyl)-1,2-dimethyl-5-nitro-1H-imidazole

: 1400916-24-6
4-[4-(4-methoxyphenoxy)-3-nitrophenyl]-1,2-dimethyl-5-nitro-1H-imidazole

Guidance literature:: Multi-step reaction with 3 steps

1: 4a,9a-dihydro-9,9-dimethyl-4,5-bis(diphenylphosphino)-xanthene; 4-methoxyphenylboronic acid; caesium carbonate; tetrabutylammomium bromide / 1,2-dimethoxyethane / 120 h / 70 °C / Inert atmosphere

2: potassium hydroxide / dimethyl sulfoxide / 168 h / 80 °C

3: 4-methoxyphenylboronic acid; potassium hydroxide / 48 h / 80 °C

With 4a,9a-dihydro-9,9-dimethyl-4,5-bis(diphenylphosphino)-xanthene; 4-methoxyphenylboronic acid; tetrabutylammomium bromide; caesium carbonate; potassium hydroxide; In 1,2-dimethoxyethane; dimethyl sulfoxide; 1: |Suzuki-Miyaura Coupling;
DOI:10.1016/j.tetlet.2012.07.107