(R)-N-(4-pentenyl)-N-pentyl γ-benzyl-N_α-t-butoxycarbonylglutamic acid amide

Base Information

Chemical Name:(R)-N-(4-pentenyl)-N-pentyl γ-benzyl-N_α-t-butoxycarbonylglutamic acid amide
CAS No.:263247-61-6
Molecular Formula:C₂₇H₄₂N₂O₅
Molecular Weight:474.641
Hs Code.:

(R)-N-(4-pentenyl)-N-pentyl γ-benzyl-N<sub>α</sub>-t-butoxycarbonylglutamic acid amide

Synonyms:(R)-N-(4-pentenyl)-N-pentyl γ-benzyl-N_α-t-butoxycarbonylglutamic acid amide

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Chemical Property of (R)-N-(4-pentenyl)-N-pentyl γ-benzyl-N_α-t-butoxycarbonylglutamic acid amide

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Technology Process of (R)-N-(4-pentenyl)-N-pentyl γ-benzyl-N_α-t-butoxycarbonylglutamic acid amide

There total 6 articles about (R)-N-(4-pentenyl)-N-pentyl γ-benzyl-N_α-t-butoxycarbonylglutamic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 35793-73-8
N-(tert-butyloxycarbonyl)-γ-benzyl-D-glutamic acid

: 263247-59-2
N-(4-pentenyl)-N-pentylamine

: 263247-61-6
(R)-N-(4-pentenyl)-N-pentyl γ-benzyl-N_α-t-butoxycarbonylglutamic acid amide

Guidance literature:: With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; In dichloromethane; at 10 - 20 ℃; for 3.5h;
DOI:10.1002/(SICI)1099-1344(200001)43:1<77::AID-JLCR292>3.0.CO;2-V

Reference yield:

: 821-09-0
n-Pent-4-enyl alcohol

: 263247-61-6
(R)-N-(4-pentenyl)-N-pentyl γ-benzyl-N_α-t-butoxycarbonylglutamic acid amide

Guidance literature:: Multi-step reaction with 3 steps

1: 30 percent / pyridinium chlorochromate / CH₂Cl₂ / 1.5 h / 20 °C

2: 40 percent / sodium cyanoborohydride; HCl; 3 Angstroem molecular sieves / methanol / 72 h / 20 °C / pH 7

3: 72 percent / bis(2-oxo-3-oxazolidinyl)phosphinic chloride / CH₂Cl₂ / 3.5 h / 10 - 20 °C

With hydrogenchloride; 3 A molecular sieve; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; sodium cyanoborohydride; pyridinium chlorochromate; In methanol; dichloromethane; 1: Oxidation / 2: reductive amination / 3: amidation;
DOI:10.1002/(SICI)1099-1344(200001)43:1<77::AID-JLCR292>3.0.CO;2-V

Reference yield:

: 2100-17-6
4-pentenal

: 263247-61-6
(R)-N-(4-pentenyl)-N-pentyl γ-benzyl-N_α-t-butoxycarbonylglutamic acid amide

Guidance literature:: Multi-step reaction with 2 steps

1: 40 percent / sodium cyanoborohydride; HCl; 3 Angstroem molecular sieves / methanol / 72 h / 20 °C / pH 7

2: 72 percent / bis(2-oxo-3-oxazolidinyl)phosphinic chloride / CH₂Cl₂ / 3.5 h / 10 - 20 °C

With hydrogenchloride; 3 A molecular sieve; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; sodium cyanoborohydride; In methanol; dichloromethane; 1: reductive amination / 2: amidation;
DOI:10.1002/(SICI)1099-1344(200001)43:1<77::AID-JLCR292>3.0.CO;2-V