alpha,alpha-Diphenyl-4-piperidineacetamide

Base Information

Chemical Name:alpha,alpha-Diphenyl-4-piperidineacetamide
CAS No.:103887-43-0
Molecular Formula:C₁₉H₂₂N₂O
Molecular Weight:294.396
Hs Code.:
DSSTox Substance ID:DTXSID801297735

Synonyms:alpha,alpha-Diphenyl-4-piperidineacetamide;SCHEMBL959566;DTXSID801297735;103887-43-0

Suppliers and Price of alpha,alpha-Diphenyl-4-piperidineacetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of alpha,alpha-Diphenyl-4-piperidineacetamide

Chemical Property:

XLogP3:2.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:4
Exact Mass:294.173213330
Heavy Atom Count:22
Complexity:346

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CNCCC1C(C2=CC=CC=C2)(C3=CC=CC=C3)C(=O)N

Technology Process of alpha,alpha-Diphenyl-4-piperidineacetamide

There total 5 articles about alpha,alpha-Diphenyl-4-piperidineacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 111952-30-8
α,α-diphenyl-4-piperidineacetonitrile

: 103887-43-0
α,α-diphenyl-4-piperidineacetamide

Guidance literature:: With sulfuric acid; In water; at 90 ℃;
DOI:10.1021/jm00121a022

Reference yield:

: 5382-16-1
4-HYDROXYPIPERIDINE

: 103887-43-0
α,α-diphenyl-4-piperidineacetamide

Guidance literature:: Multi-step reaction with 4 steps

1: 73 percent / pyridine / 25 °C

2: 1) NaH / 1) toluene, reflux, 2 h; 2) reflux, overnight

3: 48percent aq. HBr, phenol / 3.5 h / Heating

4: 67 percent / conc. H₂SO₄ / H₂O / 90 °C

With pyridine; sulfuric acid; hydrogen bromide; sodium hydride; phenol; In water;
DOI:10.1021/jm00121a022

Reference yield:

: 101767-94-6
1-<(4-methylphenyl)sulfonyl>-4-piperidinol 4-methylbenzenesulfonate ester

: 103887-43-0
α,α-diphenyl-4-piperidineacetamide

Guidance literature:: Multi-step reaction with 3 steps

1: 1) NaH / 1) toluene, reflux, 2 h; 2) reflux, overnight

2: 48percent aq. HBr, phenol / 3.5 h / Heating

3: 67 percent / conc. H₂SO₄ / H₂O / 90 °C

With sulfuric acid; hydrogen bromide; sodium hydride; phenol; In water;
DOI:10.1021/jm00121a022