tert-butyl 4-(2,4-dioxothiazolidin-3-yl)-3-fluoropiperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-(2,4-dioxothiazolidin-3-yl)-3-fluoropiperidine-1-carboxylate
CAS No.:1548128-85-3
Molecular Formula:C₁₃H₁₉FN₂O₄S
Molecular Weight:318.369
Hs Code.:

Synonyms:tert-butyl 4-(2,4-dioxothiazolidin-3-yl)-3-fluoropiperidine-1-carboxylate

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Chemical Property of tert-butyl 4-(2,4-dioxothiazolidin-3-yl)-3-fluoropiperidine-1-carboxylate

Chemical Property:

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Technology Process of tert-butyl 4-(2,4-dioxothiazolidin-3-yl)-3-fluoropiperidine-1-carboxylate

There total 1 articles about tert-butyl 4-(2,4-dioxothiazolidin-3-yl)-3-fluoropiperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 85838-94-4
N-Boc-1,2,3,6-tetrahydropyridine

: 1548128-85-3
tert-butyl 4-(2,4-dioxothiazolidin-3-yl)-3-fluoropiperidine-1-carboxylate

: 1548129-41-4
C₁₃H₁₉FN₂O₄S

Guidance literature:: Multi-step reaction with 2 steps

1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 25 h / 0 - 20 °C

2.1: magnesium(II) perchlorate / N,N-dimethyl-formamide / 12.3 h / 20 - 115 °C

2.2: 23 h / 0 - 20 °C

With magnesium(II) perchlorate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/op400325r

Reference yield: 60.0%

: 1312704-84-9
1-[4-chloro-2-(trifluoromethyl)benzyl]-1H-indazole-5-carbaldehyde

: 1548128-85-3
tert-butyl 4-(2,4-dioxothiazolidin-3-yl)-3-fluoropiperidine-1-carboxylate

: 1548129-12-9
C₂₉H₂₇ClF₄N₄O₄S

Guidance literature:: With piperidine; benzoic acid; In toluene; Reflux;
DOI:10.1021/op400325r

Reference yield:

: 1548128-85-3
tert-butyl 4-(2,4-dioxothiazolidin-3-yl)-3-fluoropiperidine-1-carboxylate

: 1351571-42-0
(5Z)-5-({1-[4-chloro-2-(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-3-(3R,4R)-(3-fluoro-1-methylpiperidin-4-yl)-1,3-thiazolidine-2,4-dione

Guidance literature:: Multi-step reaction with 4 steps

1.1: Ciralpak AD / methanol / 30 °C / Resolution of racemate

2.1: dichloromethane / 6.3 h / 20 °C

3.1: dichloromethane; water / 0.17 h / 20 °C

3.2: 0.17 h / 20 °C

3.3: 22 h / 20 °C

4.1: toluene / 0.08 h / 20 °C

4.2: 86 h / 111 - 113 °C / Darkness

With Ciralpak AD; In methanol; dichloromethane; water; toluene;
DOI:10.1021/op400325r