Spiro[1,3-dioxolane-2,5-[5H]inden]-1-ol, octahydro-7a-methyl-, (1S,3aR,7aS)- (9CI)

Base Information

Chemical Name:Spiro[1,3-dioxolane-2,5-[5H]inden]-1-ol, octahydro-7a-methyl-, (1S,3aR,7aS)- (9CI)
CAS No.:820962-41-2
Molecular Formula:C₁₂H₂₀O₃
Molecular Weight:212.289
Hs Code.:
Mol file:820962-41-2.mol

Synonyms:Spiro[1,3-dioxolane-2,5-[5H]inden]-1-ol, octahydro-7a-methyl-, (1S,3aR,7aS)- (9CI)

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Chemical Property of Spiro[1,3-dioxolane-2,5-[5H]inden]-1-ol, octahydro-7a-methyl-, (1S,3aR,7aS)- (9CI)

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Technology Process of Spiro[1,3-dioxolane-2,5-[5H]inden]-1-ol, octahydro-7a-methyl-, (1S,3aR,7aS)- (9CI)

There total 11 articles about Spiro[1,3-dioxolane-2,5-[5H]inden]-1-ol, octahydro-7a-methyl-, (1S,3aR,7aS)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 195211-56-4
(1S,3aS,7aS)-1-Hydroxy-7a-methyl-octahydro-inden-5-one

: 107-21-1
ethylene glycol

: 1233660-89-3,820962-41-2
(1'S,3a'S,7a'S)-7a'-methyloctahydrospiro([1,3]dioxolane-2,5'-inden)-1'-ol

Guidance literature:: With toluene-4-sulfonic acid; In benzene; for 2h; Inert atmosphere; Reflux;
DOI:10.1021/jo300726z

Reference yield: 65.0%

: 40574-06-9
(1S,3aR,7aS)-1-hydroxy-7a-methylhexahydro-1H-inden-5(6H)-one

: 107-21-1
ethylene glycol

: 820962-41-2
(1S,3aR,7aS)-7a-methyloctahydrospiro[indene-5,2′-[1,3]dioxolan]-1-ol

Guidance literature:: With toluene-4-sulfonic acid; In benzene; at 105 ℃; for 7.5h; Dean-Stark;
DOI:10.1021/jacs.8b12552

Reference yield:

: 59974-82-2,61490-25-3,61490-26-4,80374-04-5,53662-92-3
(1S,3aS,7aS)-1-(1,1-dimethylethoxy)octahydro-7a-methyl-5H-inden-5-one

: 1233660-89-3,820962-41-2
(1'S,3a'S,7a'S)-7a'-methyloctahydrospiro([1,3]dioxolane-2,5'-inden)-1'-ol

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / ethanol / 4 h / Inert atmosphere; Reflux

2: toluene-4-sulfonic acid / benzene / 2 h / Inert atmosphere; Reflux

With hydrogenchloride; toluene-4-sulfonic acid; In ethanol; benzene;
DOI:10.1021/jo300726z