4-(benzyl-{2-[(2,5-diphenyl-oxazole-4-carbonyl)-amino]-ethyl}-carbamoyl)-2-[2-(2-methoxy-ethoxy)-acetylamino]-butyric acid methyl ester

Base Information

Chemical Name:4-(benzyl-{2-[(2,5-diphenyl-oxazole-4-carbonyl)-amino]-ethyl}-carbamoyl)-2-[2-(2-methoxy-ethoxy)-acetylamino]-butyric acid methyl ester
CAS No.:289906-26-9
Molecular Formula:C₃₆H₄₀N₄O₈
Molecular Weight:656.736
Hs Code.:

Synonyms:4-(benzyl-{2-[(2,5-diphenyl-oxazole-4-carbonyl)-amino]-ethyl}-carbamoyl)-2-[2-(2-methoxy-ethoxy)-acetylamino]-butyric acid methyl ester

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Chemical Property of 4-(benzyl-{2-[(2,5-diphenyl-oxazole-4-carbonyl)-amino]-ethyl}-carbamoyl)-2-[2-(2-methoxy-ethoxy)-acetylamino]-butyric acid methyl ester

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Technology Process of 4-(benzyl-{2-[(2,5-diphenyl-oxazole-4-carbonyl)-amino]-ethyl}-carbamoyl)-2-[2-(2-methoxy-ethoxy)-acetylamino]-butyric acid methyl ester

There total 10 articles about 4-(benzyl-{2-[(2,5-diphenyl-oxazole-4-carbonyl)-amino]-ethyl}-carbamoyl)-2-[2-(2-methoxy-ethoxy)-acetylamino]-butyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 16024-56-9
2-(2-methoxyethoxy)acetic acid

: 2-amino-4-(benzyl-{2-[(2,5-diphenyl-oxazole-4-carbonyl)-amino]-ethyl}-carbamoyl)-butyric acid methyl ester

: 289906-26-9
4-(benzyl-{2-[(2,5-diphenyl-oxazole-4-carbonyl)-amino]-ethyl}-carbamoyl)-2-[2-(2-methoxy-ethoxy)-acetylamino]-butyric acid methyl ester

Guidance literature:: With triethylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In tetrahydrofuran; at 0 - 22 ℃;
DOI:10.1016/S0968-0896(00)00069-9

Reference yield:

: 617-65-2,21675-62-7,23009-64-5,25104-13-6,84960-48-5,25513-46-6
Glutamic acid

: 289906-26-9
4-(benzyl-{2-[(2,5-diphenyl-oxazole-4-carbonyl)-amino]-ethyl}-carbamoyl)-2-[2-(2-methoxy-ethoxy)-acetylamino]-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 9 steps

1.1: chlorotrimethylsilane / 22 h / 22 °C

2.1: aq. Na₂CO₃ / dioxane / 0.08 h / 0 °C

2.2: 8.76 g / dioxane / 17 h / 22 °C

3.1: 6.26 g / KHCO₃ / dimethylformamide / 16 h / 22 °C

4.1: morpholine; Pd(PPh₃)4 / tetrahydrofuran / 0.5 h / 22 °C

5.1: 294 mg / (i-Pr)2NEt; PyBroP / tetrahydrofuran / 0 - 22 °C

6.1: AcOH; Pd(PPh₃)4; n-Bu₃SnH / CH₂Cl₂ / 0.5 h / 22 °C

7.1: 819 mg / Et₃N; PyBroP / tetrahydrofuran / 0 - 22 °C

8.1: Zn; AcOH / tetrahydrofuran / 1 h / 22 °C

9.1: 68.2 mg / Et₃N; PyBroP / tetrahydrofuran / 0 - 22 °C

With morpholine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; chloro-trimethyl-silane; tri-n-butyl-tin hydride; sodium carbonate; potassium hydrogencarbonate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; zinc; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; 1.1: Esterification / 2.1: deprotonation / 2.2: Acylation / 3.1: Esterification / 4.1: deallylation / 5.1: Acylation / 6.1: deprotection / 7.1: Acylation / 8.1: deprotection / 9.1: Acylation;
DOI:10.1016/S0968-0896(00)00069-9

Reference yield:

: 18735-78-9
2,5-diphenyloxazole-4-carboxylic acid

: 289906-26-9
4-(benzyl-{2-[(2,5-diphenyl-oxazole-4-carbonyl)-amino]-ethyl}-carbamoyl)-2-[2-(2-methoxy-ethoxy)-acetylamino]-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 819 mg / Et₃N; PyBroP / tetrahydrofuran / 0 - 22 °C

2: Zn; AcOH / tetrahydrofuran / 1 h / 22 °C

3: 68.2 mg / Et₃N; PyBroP / tetrahydrofuran / 0 - 22 °C

With acetic acid; triethylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; zinc; In tetrahydrofuran; 1: Acylation / 2: deprotection / 3: Acylation;
DOI:10.1016/S0968-0896(00)00069-9