2-({2-[(4-bromophenyl)carbonyl]-4-chlorophenyl}oxy)-N-[2-methyl-4-(1-oxido-4-thiomorpholinyl)phenyl]acetamide

Base Information

Chemical Name:2-({2-[(4-bromophenyl)carbonyl]-4-chlorophenyl}oxy)-N-[2-methyl-4-(1-oxido-4-thiomorpholinyl)phenyl]acetamide
CAS No.:329939-35-7
Molecular Formula:C₂₆H₂₄BrClN₂O₄S
Molecular Weight:575.911
Hs Code.:

Synonyms:2-({2-[(4-bromophenyl)carbonyl]-4-chlorophenyl}oxy)-N-[2-methyl-4-(1-oxido-4-thiomorpholinyl)phenyl]acetamide

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Chemical Property of 2-({2-[(4-bromophenyl)carbonyl]-4-chlorophenyl}oxy)-N-[2-methyl-4-(1-oxido-4-thiomorpholinyl)phenyl]acetamide

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Technology Process of 2-({2-[(4-bromophenyl)carbonyl]-4-chlorophenyl}oxy)-N-[2-methyl-4-(1-oxido-4-thiomorpholinyl)phenyl]acetamide

There total 8 articles about 2-({2-[(4-bromophenyl)carbonyl]-4-chlorophenyl}oxy)-N-[2-methyl-4-(1-oxido-4-thiomorpholinyl)phenyl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

: 329943-94-4
2-methyl-4-(1-oxido-4-thiomorpholinyl)aniline

: 329944-24-3
({2-[(4-bromophenyl)carbonyl]-4-chlorophenyl}oxy)acetic acid

: 329939-35-7
2-({2-[(4-bromophenyl)carbonyl]-4-chlorophenyl}oxy)-N-[2-methyl-4-(1-oxido-4-thiomorpholinyl)phenyl]acetamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1021/jm050670l

Reference yield:

: 329943-87-5
4-(3-methyl-4-nitrophenyl)thiomorpholine

: 329939-35-7
2-({2-[(4-bromophenyl)carbonyl]-4-chlorophenyl}oxy)-N-[2-methyl-4-(1-oxido-4-thiomorpholinyl)phenyl]acetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 3-chloroperoxybenzoic acid / CH₂Cl₂ / -20 - 20 °C

1.2: 4.27 g / H₂ / Pd/C / ethanol; tetrahydrofuran; methanol / 3102.89 Torr

2.1: 15 percent / 1-hydroxybenzotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; Et₃N / dimethylformamide / 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm050670l

Reference yield:

: (4-bromo-phenyl)-(5-chloro-2-methoxy-phenyl)-methanone

: 329939-35-7
2-({2-[(4-bromophenyl)carbonyl]-4-chlorophenyl}oxy)-N-[2-methyl-4-(1-oxido-4-thiomorpholinyl)phenyl]acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: BBr₃ / CH₂Cl₂ / 2.08 h / -78 - 20 °C

2: K₂CO₃ / acetone / 4.33 h / Heating

3: 10.71 g / aq. LiOH / ethanol; tetrahydrofuran / 2.75 h / 20 °C

4: 15 percent / 1-hydroxybenzotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; Et₃N / dimethylformamide / 20 °C

With lithium hydroxide; boron tribromide; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm050670l