4-(3-Methyl-4-nitrophenyl)thiomorpholine

Base Information

Chemical Name:4-(3-Methyl-4-nitrophenyl)thiomorpholine
CAS No.:329943-87-5
Molecular Formula:C11H14N2O2S
Molecular Weight:238.31
Hs Code.:
DSSTox Substance ID:DTXSID001276662

Synonyms:4-(3-methyl-4-nitrophenyl)thiomorpholine;329943-87-5;SCHEMBL14419240;DTXSID001276662

Suppliers and Price of 4-(3-Methyl-4-nitrophenyl)thiomorpholine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(3-Methyl-4-nitrophenyl)thiomorpholine

Chemical Property:

XLogP3:3.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:238.07759887
Heavy Atom Count:16
Complexity:251

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=C(C=CC(=C1)N2CCSCC2)[N+](=O)[O-]

Technology Process of 4-(3-Methyl-4-nitrophenyl)thiomorpholine

There total 1 articles about 4-(3-Methyl-4-nitrophenyl)thiomorpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 123-90-0
Thiomorpholin

: 446-33-3
5-Fluoro-2-nitrotoluene

: 329943-87-5
4-(3-methyl-4-nitrophenyl)thiomorpholine

Guidance literature:: In dimethyl sulfoxide; at 75 - 100 ℃; for 6h;
DOI:10.1021/jm050670l

Reference yield:

: 329943-87-5
4-(3-methyl-4-nitrophenyl)thiomorpholine

: 329943-94-4
2-methyl-4-(1-oxido-4-thiomorpholinyl)aniline

Guidance literature:: 4-(3-methyl-4-nitrophenyl)thiomorpholine; With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at -20 - 20 ℃;

With hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; under 3102.89 Torr;
DOI:10.1021/jm050670l

Reference yield:

: 329943-87-5
4-(3-methyl-4-nitrophenyl)thiomorpholine

: 329939-33-5
2-({2-[(2-bromophenyl)carbonyl]-4-chlorophenyl}oxy)-N-[2-methyl-4-(1-oxido-4-thiomorpholinyl)phenyl]acetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 3-chloroperoxybenzoic acid / CH₂Cl₂ / -20 - 20 °C

1.2: 4.27 g / H₂ / Pd/C / ethanol; tetrahydrofuran; methanol / 3102.89 Torr

2.1: 22 percent / 1-hydroxybenzotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; Et₃N / dimethylformamide / 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm050670l