4-(4,5-Bis(4-methoxyphenyl)oxazol-2-yl)-1-(N-hydroxy-N-ethylcarbamoyl)piperidine

Base Information

Chemical Name:4-(4,5-Bis(4-methoxyphenyl)oxazol-2-yl)-1-(N-hydroxy-N-ethylcarbamoyl)piperidine
CAS No.:951743-35-4
Molecular Formula:C₂₅H₂₉N₃O₅
Molecular Weight:451.522
Hs Code.:

Synonyms:4-(4,5-Bis(4-methoxyphenyl)oxazol-2-yl)-1-(N-hydroxy-N-ethylcarbamoyl)piperidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(4,5-Bis(4-methoxyphenyl)oxazol-2-yl)-1-(N-hydroxy-N-ethylcarbamoyl)piperidine

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Technology Process of 4-(4,5-Bis(4-methoxyphenyl)oxazol-2-yl)-1-(N-hydroxy-N-ethylcarbamoyl)piperidine

There total 7 articles about 4-(4,5-Bis(4-methoxyphenyl)oxazol-2-yl)-1-(N-hydroxy-N-ethylcarbamoyl)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.0%

: 74-96-4
ethyl bromide

: 951743-34-3
4-(4,5-bis(4-methoxyphenyl)oxazol-2-yl)-1-(N-hydroxycarbamoyl)piperidine

: 951743-35-4
4-(4,5-Bis(4-methoxyphenyl)oxazol-2-yl)-1-(N-hydroxy-N-ethylcarbamoyl)piperidine

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

Reference yield:

: 498-94-2
isonipecotic acid

: 951743-35-4
4-(4,5-Bis(4-methoxyphenyl)oxazol-2-yl)-1-(N-hydroxy-N-ethylcarbamoyl)piperidine

Guidance literature:: Multi-step reaction with 7 steps

1: sodium hydrogencarbonate / water / 20 h / 20 °C

2: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1.5 - 2 h / 0 - 20 °C

3: triethylamine / dichloromethane / 15 h / 0 °C

4: ammonium acetate; acetic acid / 17 h / 90 °C

5: hydrogen / palladium 10% on activated carbon / ethanol / 3 h / 20 °C

6: triethylamine / acetonitrile / 5 h / 20 °C

7: caesium carbonate / N,N-dimethyl-formamide / 18 h / 20 °C

With oxalyl dichloride; ammonium acetate; hydrogen; sodium hydrogencarbonate; caesium carbonate; acetic acid; triethylamine; palladium 10% on activated carbon; N,N-dimethyl-formamide; In ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 951744-05-1
4-(1,2-Bis(4-methoxyphenyl)-2-oxoethyl) 1-benzyloxycarbonyl-4-piperidinecarboxylate

: 951743-35-4
4-(4,5-Bis(4-methoxyphenyl)oxazol-2-yl)-1-(N-hydroxy-N-ethylcarbamoyl)piperidine

Guidance literature:: Multi-step reaction with 4 steps

1: ammonium acetate; acetic acid / 17 h / 90 °C

2: hydrogen / palladium 10% on activated carbon / ethanol / 3 h / 20 °C

3: triethylamine / acetonitrile / 5 h / 20 °C

4: caesium carbonate / N,N-dimethyl-formamide / 18 h / 20 °C

With ammonium acetate; hydrogen; caesium carbonate; acetic acid; triethylamine; palladium 10% on activated carbon; In ethanol; N,N-dimethyl-formamide; acetonitrile;