(2S,4S)-5-Biphenyl-4-yl-2-hydroxymethyl-4-[(3H-[1,2,3]triazole-4-carbonyl)-amino]-pentanoic acid 2-methoxy-ethyl ester

Base Information

Chemical Name:(2S,4S)-5-Biphenyl-4-yl-2-hydroxymethyl-4-[(3H-[1,2,3]triazole-4-carbonyl)-amino]-pentanoic acid 2-methoxy-ethyl ester
CAS No.:1394048-72-6
Molecular Formula:C₂₄H₂₈N₄O₅
Molecular Weight:452.51
Hs Code.:

Synonyms:(2S,4S)-5-Biphenyl-4-yl-2-hydroxymethyl-4-[(3H-[1,2,3]triazole-4-carbonyl)-amino]-pentanoic acid 2-methoxy-ethyl ester

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Chemical Property of (2S,4S)-5-Biphenyl-4-yl-2-hydroxymethyl-4-[(3H-[1,2,3]triazole-4-carbonyl)-amino]-pentanoic acid 2-methoxy-ethyl ester

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Technology Process of (2S,4S)-5-Biphenyl-4-yl-2-hydroxymethyl-4-[(3H-[1,2,3]triazole-4-carbonyl)-amino]-pentanoic acid 2-methoxy-ethyl ester

There total 10 articles about (2S,4S)-5-Biphenyl-4-yl-2-hydroxymethyl-4-[(3H-[1,2,3]triazole-4-carbonyl)-amino]-pentanoic acid 2-methoxy-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 109-86-4,95507-80-5
2-methoxy-ethanol

: 1394048-70-4
(2S,4S)-5-Biphenyl-4-yl-2-hydroxymethyl-4-[(3H-[1,2,3]triazole-4-carbonyl)-amino]-pentanoic acid

: 1394048-72-6
(2S,4S)-5-Biphenyl-4-yl-2-hydroxymethyl-4-[(3H-[1,2,3]triazole-4-carbonyl)-amino]-pentanoic acid 2-methoxy-ethyl ester

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 60 ℃; for 4h; Inert atmosphere;

Reference yield:

: 128779-47-5
(2R)-3-(biphenyl-4-yl)-2-[(tert-butoxycarbonyl)amino]propanoic acid

: 1394048-72-6
(2S,4S)-5-Biphenyl-4-yl-2-hydroxymethyl-4-[(3H-[1,2,3]triazole-4-carbonyl)-amino]-pentanoic acid 2-methoxy-ethyl ester

Guidance literature:: Multi-step reaction with 11 steps

1.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 9 h / -5 °C / Inert atmosphere

2.1: acetic acid / dichloromethane / 0.5 h / -5 °C / Inert atmosphere

2.2: 2 h / -5 °C / Inert atmosphere

3.1: toluene / 3 h / Inert atmosphere; Reflux

4.1: 3 h / 80 °C / Inert atmosphere

5.1: water; tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

5.2: pH 7

6.1: acetic acid / ethanol; tetrahydrofuran / 0.5 h / -5 °C / Inert atmosphere

6.2: 2 h / -5 °C

6.3: pH 7

7.1: potassium carbonate / 17 h / 0 - 20 °C / Inert atmosphere

8.1: dichloromethane / 1 h / 20 °C / Inert atmosphere

9.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 0.08 h / 20 °C / Inert atmosphere

9.2: 2 h

10.1: sodium hydroxide; water / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

11.1: hydrogenchloride / 1,4-dioxane / 4 h / 60 °C / Inert atmosphere

With hydrogenchloride; dmap; water; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; HATU; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; toluene;

Reference yield:

: 1174130-65-4
(R)-5-biphenyl-4-ylmethyl-3-[1-dimethylaminometh-(E/Z)-ylidene]-2-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester

: 1394048-72-6
(2S,4S)-5-Biphenyl-4-yl-2-hydroxymethyl-4-[(3H-[1,2,3]triazole-4-carbonyl)-amino]-pentanoic acid 2-methoxy-ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: water; tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

1.2: pH 7

2.1: acetic acid / ethanol; tetrahydrofuran / 0.5 h / -5 °C / Inert atmosphere

2.2: 2 h / -5 °C

2.3: pH 7

3.1: potassium carbonate / 17 h / 0 - 20 °C / Inert atmosphere

4.1: dichloromethane / 1 h / 20 °C / Inert atmosphere

5.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 0.08 h / 20 °C / Inert atmosphere

5.2: 2 h

6.1: sodium hydroxide; water / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

7.1: hydrogenchloride / 1,4-dioxane / 4 h / 60 °C / Inert atmosphere

With hydrogenchloride; water; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water;