(2S,4S)-5-Biphenyl-4-yl-2-hydroxymethyl-4-[(3H-[1,2,3]triazole-4-carbonyl)-amino]-pentanoic acid

Base Information

Chemical Name:(2S,4S)-5-Biphenyl-4-yl-2-hydroxymethyl-4-[(3H-[1,2,3]triazole-4-carbonyl)-amino]-pentanoic acid
CAS No.:1394048-70-4
Molecular Formula:C₂₁H₂₂N₄O₄
Molecular Weight:394.43
Hs Code.:

Synonyms:(2S,4S)-5-Biphenyl-4-yl-2-hydroxymethyl-4-[(3H-[1,2,3]triazole-4-carbonyl)-amino]-pentanoic acid

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Chemical Property of (2S,4S)-5-Biphenyl-4-yl-2-hydroxymethyl-4-[(3H-[1,2,3]triazole-4-carbonyl)-amino]-pentanoic acid

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Technology Process of (2S,4S)-5-Biphenyl-4-yl-2-hydroxymethyl-4-[(3H-[1,2,3]triazole-4-carbonyl)-amino]-pentanoic acid

There total 9 articles about (2S,4S)-5-Biphenyl-4-yl-2-hydroxymethyl-4-[(3H-[1,2,3]triazole-4-carbonyl)-amino]-pentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1394048-69-1
(2S,4S)-5-Biphenyl-4-yl-2-hydroxymethyl-4-[(3H-[1,2,3]triazole-4-carbonyl)-amino]-pentanoic acid ethyl ester

: 1394048-70-4
(2S,4S)-5-Biphenyl-4-yl-2-hydroxymethyl-4-[(3H-[1,2,3]triazole-4-carbonyl)-amino]-pentanoic acid

Guidance literature:: With water; sodium hydroxide; In tetrahydrofuran; at 20 ℃; for 1h; Inert atmosphere;

Reference yield:

: 128779-47-5
(2R)-3-(biphenyl-4-yl)-2-[(tert-butoxycarbonyl)amino]propanoic acid

: 1394048-70-4
(2S,4S)-5-Biphenyl-4-yl-2-hydroxymethyl-4-[(3H-[1,2,3]triazole-4-carbonyl)-amino]-pentanoic acid

Guidance literature:: Multi-step reaction with 10 steps

1.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 9 h / -5 °C / Inert atmosphere

2.1: acetic acid / dichloromethane / 0.5 h / -5 °C / Inert atmosphere

2.2: 2 h / -5 °C / Inert atmosphere

3.1: toluene / 3 h / Inert atmosphere; Reflux

4.1: 3 h / 80 °C / Inert atmosphere

5.1: water; tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

5.2: pH 7

6.1: acetic acid / ethanol; tetrahydrofuran / 0.5 h / -5 °C / Inert atmosphere

6.2: 2 h / -5 °C

6.3: pH 7

7.1: potassium carbonate / 17 h / 0 - 20 °C / Inert atmosphere

8.1: dichloromethane / 1 h / 20 °C / Inert atmosphere

9.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 0.08 h / 20 °C / Inert atmosphere

9.2: 2 h

10.1: sodium hydroxide; water / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

With dmap; water; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; HATU; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; water; toluene;

Reference yield:

: 1174130-65-4
(R)-5-biphenyl-4-ylmethyl-3-[1-dimethylaminometh-(E/Z)-ylidene]-2-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester

: 1394048-70-4
(2S,4S)-5-Biphenyl-4-yl-2-hydroxymethyl-4-[(3H-[1,2,3]triazole-4-carbonyl)-amino]-pentanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: water; tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

1.2: pH 7

2.1: acetic acid / ethanol; tetrahydrofuran / 0.5 h / -5 °C / Inert atmosphere

2.2: 2 h / -5 °C

2.3: pH 7

3.1: potassium carbonate / 17 h / 0 - 20 °C / Inert atmosphere

4.1: dichloromethane / 1 h / 20 °C / Inert atmosphere

5.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 0.08 h / 20 °C / Inert atmosphere

5.2: 2 h

6.1: sodium hydroxide; water / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

With water; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; water;