(R)-benzyl 2-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)pyrrolidine-1-carboxylate

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Chemical Name:(R)-benzyl 2-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)pyrrolidine-1-carboxylate
CAS No.:1072811-64-3
Molecular Formula:C₁₈H₁₈N₄O₃
Molecular Weight:338.366
Hs Code.:

Synonyms:(R)-benzyl 2-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)pyrrolidine-1-carboxylate

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Chemical Property of (R)-benzyl 2-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)pyrrolidine-1-carboxylate

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Technology Process of (R)-benzyl 2-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)pyrrolidine-1-carboxylate

There total 3 articles about (R)-benzyl 2-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: (R)-benzyl 2-(2-carbamoyl-1H-pyrrol-1-ylcarbamoyl)pyrrolidine-1-carboxylate

: 1072811-64-3
(R)-benzyl 2-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)pyrrolidine-1-carboxylate

Guidance literature:: (R)-benzyl 2-(2-carbamoyl-1H-pyrrol-1-ylcarbamoyl)pyrrolidine-1-carboxylate; With potassium hydroxide; In ethanol; water; for 72h; Heating / reflux;

With hydrogenchloride; In tetrahydrofuran; ethanol; water; pH=9;

Reference yield:

: C₁₀H₁₂N₄O

: 501-53-1,94274-21-2
benzyl chloroformate

: 1072811-64-3
(R)-benzyl 2-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)pyrrolidine-1-carboxylate

Guidance literature:: With sodium hydrogencarbonate; In water;
DOI:10.1016/j.bmcl.2010.07.045

Reference yield:

: 6404-31-5
Z-D-proline

: 1072811-64-3
(R)-benzyl 2-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 20 °C

2.1: potassium hydroxide / ethanol; water / 72 h / Heating / reflux

2.2: pH 9

With potassium hydroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; ethanol; water;