(S)-1-{1′-[1-(2-propynyl)]-1′2′-dihydro-2′-oxospiro(1,3-dioxane-2,3′-[3H]indol)-5′-sulfonyl}-2-(2,4-difluorophenoxymethyl)pyrrolidine

Base Information

• Chemical Name: (S)-1-{1′-[1-(2-propynyl)]-1′2′-dihydro-2′-oxospiro(1,3-dioxane-2,3′-[3H]indol)-5′-sulfonyl}-2-(2,4-difluorophenoxymethyl)pyrrolidine
• CAS No.: 1215005-85-8
• Molecular Formula: C₂₅H₂₄F₂N₂O₆S
• Molecular Weight: 518.538
• Mol file: 1215005-85-8.mol

Synonyms:(S)-1-{1′-[1-(2-propynyl)]-1′2′-dihydro-2′-oxospiro(1,3-dioxane-2,3′-[3H]indol)-5′-sulfonyl}-2-(2,4-difluorophenoxymethyl)pyrrolidine

Chemical Property of (S)-1-{1′-[1-(2-propynyl)]-1′2′-dihydro-2′-oxospiro(1,3-dioxane-2,3′-[3H]indol)-5′-sulfonyl}-2-(2,4-difluorophenoxymethyl)pyrrolidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-1-{1′-[1-(2-propynyl)]-1′2′-dihydro-2′-oxospiro(1,3-dioxane-2,3′-[3H]indol)-5′-sulfonyl}-2-(2,4-difluorophenoxymethyl)pyrrolidine

There total 1 articles about (S)-1-{1′-[1-(2-propynyl)]-1′2′-dihydro-2′-oxospiro(1,3-dioxane-2,3′-[3H]indol)-5′-sulfonyl}-2-(2,4-difluorophenoxymethyl)pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

(S)-5-(2-((2,4-difluorophenoxy)methyl)pyrrolidin-1-ylsulfonyl)-1-(prop-2-ynyl)indoline-2,3-dione (1092522-44-5) + trimethyleneglycol (504-63-2) → (S)-1-{1′-[1-(2-propynyl)]-1′2′-dihydro-2′-oxospiro(1,3-dioxane-2,3′-[3H]indol)-5′-sulfonyl}-2-(2,4-difluorophenoxymethyl)pyrrolidine (1215005-85-8)

Guidance literature:

With toluene-4-sulfonic acid; In toluene; for 24h; Reflux; Inert atmosphere;

DOI:10.1016/j.bmcl.2011.10.001

Reference yield: 80.0%

(S)-1-{1′-[1-(2-propynyl)]-1′2′-dihydro-2′-oxospiro(1,3-dioxane-2,3′-[3H]indol)-5′-sulfonyl}-2-(2,4-difluorophenoxymethyl)pyrrolidine (1215005-85-8) + tosylethylazide (113738-22-0) → C34H35F2N5O9S2 (1445830-33-0)

Guidance literature:

With copper(II) sulfate; ascorbic acid; In water; N,N-dimethyl-formamide; for 4h; Inert atmosphere;

Reference yield:

2-[18F]fluoroethylazide (894793-02-3) + (S)-1-{1′-[1-(2-propynyl)]-1′2′-dihydro-2′-oxospiro(1,3-dioxane-2,3′-[3H]indol)-5′-sulfonyl}-2-(2,4-difluorophenoxymethyl)pyrrolidine (1215005-85-8) → C27H28F2(18)FN5O6S (1346518-82-8)

Guidance literature:

With copper(ll) sulfate pentahydrate; sodium L-ascorbate; In N,N-dimethyl-formamide; acetonitrile; at 20 ℃; for 0.25h; pH=5; Inert atmosphere; aq. acetate buffer;

DOI:10.1016/j.bmcl.2011.10.001

upstream raw materials:

(S)-5-(2-((2,4-difluorophenoxy)methyl)pyrrolidin-1-ylsulfonyl)-1-(prop-2-ynyl)indoline-2,3-dione

trimethyleneglycol

Downstream raw materials:

C₂₇H₂₈F₂⁽¹⁸⁾FN₅O₆S

C₂₄H₂₂F₂⁽¹⁸⁾FN₅O₅S

C₃₄H₃₅F₂N₅O₉S₂