3-(acetoxymethyl)-3-(3-chloropropyl)-1,5-dimethyl-1,4-cyclohexadiene

Base Information

• Chemical Name: 3-(acetoxymethyl)-3-(3-chloropropyl)-1,5-dimethyl-1,4-cyclohexadiene
• CAS No.: 112043-51-3
• Molecular Formula: C₁₄H₂₁ClO₂
• Molecular Weight: 256.773
• Mol file: 112043-51-3.mol

Synonyms:3-(acetoxymethyl)-3-(3-chloropropyl)-1,5-dimethyl-1,4-cyclohexadiene

Chemical Property of 3-(acetoxymethyl)-3-(3-chloropropyl)-1,5-dimethyl-1,4-cyclohexadiene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(acetoxymethyl)-3-(3-chloropropyl)-1,5-dimethyl-1,4-cyclohexadiene

There total 2 articles about 3-(acetoxymethyl)-3-(3-chloropropyl)-1,5-dimethyl-1,4-cyclohexadiene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

acetic anhydride (108-24-7) + 3-(3-chloropropyl)-3-(hydroxymethyl)-1,5-dimethyl-1,4-cyclohexadiene (112043-50-2) → 3-(acetoxymethyl)-3-(3-chloropropyl)-1,5-dimethyl-1,4-cyclohexadiene (112043-51-3)

Guidance literature:

With pyridine; dmap; for 16h; Ambient temperature;

DOI:10.1021/jo00237a030

Reference yield:

3-(3-chloropropyl)-3-(methoxycarbonyl)-1,5-dimethyl-1,4-cyclohexadiene (111112-92-6) → 3-(acetoxymethyl)-3-(3-chloropropyl)-1,5-dimethyl-1,4-cyclohexadiene (112043-51-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / LiAlH₄ / tetrahydrofuran / 2 h / Ambient temperature

2: 98 percent / pyridine, 4-(dimethylamino)pyridine / 16 h / Ambient temperature

With pyridine; dmap; lithium aluminium tetrahydride; In tetrahydrofuran;

DOI:10.1021/jo00237a030

Reference yield: 63.0%

3-(acetoxymethyl)-3-(3-chloropropyl)-1,5-dimethyl-1,4-cyclohexadiene (112043-51-3) → 4-(acetoxymethyl)-4-(3-chloropropyl)-2,6-dimethyl-2,5-cyclohexadienone (112043-52-4)

Guidance literature:

With dipyridinium dichromate; In chloroform; Heating;

DOI:10.1016/S0040-4039(00)80377-9

upstream raw materials:

acetic anhydride

3-(3-chloropropyl)-3-(hydroxymethyl)-1,5-dimethyl-1,4-cyclohexadiene

3-(3-chloropropyl)-3-(methoxycarbonyl)-1,5-dimethyl-1,4-cyclohexadiene

Downstream raw materials:

4-(acetoxymethyl)-4-(3-chloropropyl)-2,6-dimethyl-2,5-cyclohexadienone