(RS)-N-[1-(3-FLUOROPHENYL)ETHYL]METHYLAMINE

Base Information

• Chemical Name: (RS)-N-[1-(3-FLUOROPHENYL)ETHYL]METHYLAMINE
• CAS No.: 820209-02-7
• Molecular Formula: C₉H₁₂FN
• Molecular Weight: 153.199
• Hs Code.: 2921499090
• Mol file: 820209-02-7.mol

Synonyms:(RS)-N-[1-(3-FLUOROPHENYL)ETHYL]METHYLAMINE;3-Fluoro-N-α-dimethylbenzenemethanamine

Chemical Property of (RS)-N-[1-(3-FLUOROPHENYL)ETHYL]METHYLAMINE

Chemical Property:

• Vapor Pressure: 0.971mmHg at 25°C
• Refractive Index: 1.489
• Boiling Point: 178.8°C at 760 mmHg
• Flash Point: 61.9°C
• PSA: 12.03000
• Density: 1.004g/cm³
• LogP: 2.49700

Purity/Quality:

99% ^*data from raw suppliers

alpha,N-Dimethyl-3-fluorobenzylamine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (RS)-N-[1-(3-FLUOROPHENYL)ETHYL]METHYLAMINE

There total 5 articles about (RS)-N-[1-(3-FLUOROPHENYL)ETHYL]METHYLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(3-fluorophenyl)-N-methylethan-1-imine → (R)-1-(3-fluorophenyl)ethylamine N-monomethyl (1212124-79-2,820209-02-7)

Guidance literature:

With C₃₄H₃₇FeN₃O₂Si; 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane; In hexane; toluene; at -40 - 20 ℃; for 14h; enantioselective reaction;

DOI:10.1002/anie.202006557

Reference yield:

1-(3-fluorophenyl)ethanone (455-36-7) → (R)-1-(3-fluorophenyl)ethylamine N-monomethyl (1212124-79-2,820209-02-7)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / 96 h / 20 °C / Schlenk technique; Sealed tube; Inert atmosphere; Molecular sieve

2: C₃₄H₃₇FeN₃O₂Si; 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane / toluene; hexane / 14 h / -40 - 20 °C

With C₃₄H₃₇FeN₃O₂Si; 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane; In ethanol; hexane; toluene;

DOI:10.1002/anie.202006557

Reference yield:

1-(3-fluorophenyl)-N-methylethan-1-imine → (+/-)-N-methyl-N-[α-methyl-(3-fluorobenzyl)]-amine (820209-02-7)

Guidance literature:

With methanol; sodium tetrahydroborate; at 20 ℃;

DOI:10.1002/anie.202006557

upstream raw materials:

1-(3-fluorophenyl)ethanone

Refernces

• 1、 -. "TACHYKININ RECEPTOR ANTAGONISTS". Page 29. . Retrieved 2010/02/10.