ethyl 4-chloro-2-<2-(2-methylpropoxy)anilino>-5-pyrimidinecarboxylate

Base Information

• Chemical Name: ethyl 4-chloro-2-<2-(2-methylpropoxy)anilino>-5-pyrimidinecarboxylate
• CAS No.: 124769-86-4
• Molecular Formula: C₁₇H₂₀ClN₃O₃
• Molecular Weight: 349.817
• Mol file: 124769-86-4.mol

Synonyms:ethyl 4-chloro-2-<2-(2-methylpropoxy)anilino>-5-pyrimidinecarboxylate

Chemical Property of ethyl 4-chloro-2-<2-(2-methylpropoxy)anilino>-5-pyrimidinecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 4-chloro-2-<2-(2-methylpropoxy)anilino>-5-pyrimidinecarboxylate

There total 4 articles about ethyl 4-chloro-2-<2-(2-methylpropoxy)anilino>-5-pyrimidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

ethyl 1,6-dihydro-2-[2-(2-methylpropoxy)anilino]-6-oxo-5-pyrimidinecarboxylate (98771-59-6) → ethyl 4-chloro-2-<2-(2-methylpropoxy)anilino>-5-pyrimidinecarboxylate (124769-86-4)

Guidance literature:

With N,N-diethylaniline; trichlorophosphate; In acetonitrile; for 3h; Heating;

DOI:10.1248/cpb.37.1780

Reference yield:

ethyl 3,4-dihydro-2-methylthio-4-oxopyrimidine-5-carboxylate (53554-29-3) → ethyl 4-chloro-2-<2-(2-methylpropoxy)anilino>-5-pyrimidinecarboxylate (124769-86-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 74 percent / 2 h / 130 °C

2: 54 percent / POCl₃, N,N-diethylaniline / acetonitrile / 3 h / Heating

With N,N-diethylaniline; trichlorophosphate; In acetonitrile;

DOI:10.1248/cpb.37.1780

Reference yield:

1-isobutoxy-2-nitrobenzene (56245-02-4) → ethyl 4-chloro-2-<2-(2-methylpropoxy)anilino>-5-pyrimidinecarboxylate (124769-86-4)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogen / 10percent Pd/C / methanol

2: 74 percent / 2 h / 130 °C

3: 54 percent / POCl₃, N,N-diethylaniline / acetonitrile / 3 h / Heating

With hydrogen; N,N-diethylaniline; trichlorophosphate; palladium on activated charcoal; In methanol; acetonitrile;

DOI:10.1248/cpb.37.1780

upstream raw materials:

ethyl 1,6-dihydro-2-[2-(2-methylpropoxy)anilino]-6-oxo-5-pyrimidinecarboxylate

ethyl 3,4-dihydro-2-methylthio-4-oxopyrimidine-5-carboxylate

1-isobutoxy-2-nitrobenzene

2-(2-methylpropoxy)benzenamine

Downstream raw materials:

ethyl 4-methoxy-3-<2-(2-methylpropoxy)anilino>-5-pyrimidinecarboxylate hydrochloride

4-methoxy-2-<2-(2-methylpropoxy)anilino>-5-pyrimidineacrboxylic acid