5-(4-(5-(2-(2,4-dimethoxybenzyl)-6-(2,4-dimethoxybenzylamino)isoindolin-5-ylcarbamoyl)-4-(4-methoxybenzyloxy)-1-methyl-1H-pyrazol-3-yl)phenyl)-N-methylpicolinamide

Base Information

Chemical Name:5-(4-(5-(2-(2,4-dimethoxybenzyl)-6-(2,4-dimethoxybenzylamino)isoindolin-5-ylcarbamoyl)-4-(4-methoxybenzyloxy)-1-methyl-1H-pyrazol-3-yl)phenyl)-N-methylpicolinamide
CAS No.:1197340-75-2
Molecular Formula:C₅₂H₅₃N₇O₈
Molecular Weight:904.035
Hs Code.:

5-(4-(5-(2-(2,4-dimethoxybenzyl)-6-(2,4-dimethoxybenzylamino)isoindolin-5-ylcarbamoyl)-4-(4-methoxybenzyloxy)-1-methyl-1H-pyrazol-3-yl)phenyl)-N-methylpicolinamide

Synonyms:5-(4-(5-(2-(2,4-dimethoxybenzyl)-6-(2,4-dimethoxybenzylamino)isoindolin-5-ylcarbamoyl)-4-(4-methoxybenzyloxy)-1-methyl-1H-pyrazol-3-yl)phenyl)-N-methylpicolinamide

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Chemical Property of 5-(4-(5-(2-(2,4-dimethoxybenzyl)-6-(2,4-dimethoxybenzylamino)isoindolin-5-ylcarbamoyl)-4-(4-methoxybenzyloxy)-1-methyl-1H-pyrazol-3-yl)phenyl)-N-methylpicolinamide

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Technology Process of 5-(4-(5-(2-(2,4-dimethoxybenzyl)-6-(2,4-dimethoxybenzylamino)isoindolin-5-ylcarbamoyl)-4-(4-methoxybenzyloxy)-1-methyl-1H-pyrazol-3-yl)phenyl)-N-methylpicolinamide

There total 8 articles about 5-(4-(5-(2-(2,4-dimethoxybenzyl)-6-(2,4-dimethoxybenzylamino)isoindolin-5-ylcarbamoyl)-4-(4-methoxybenzyloxy)-1-methyl-1H-pyrazol-3-yl)phenyl)-N-methylpicolinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1197340-74-1
4-(4-methoxybenzyloxy)-1-methyl-3-(4-(6-(methylcarbamoyl)pyridin-3-yl)phenyl)-1H-pyrazole-5-carboxylic acid

: 1197340-72-9
N₅,2-bis(2,4-dimethoxybenzyl)isoindoline-5,6-diamine

: 1197340-75-2
5-(4-(5-(2-(2,4-dimethoxybenzyl)-6-(2,4-dimethoxybenzylamino)isoindolin-5-ylcarbamoyl)-4-(4-methoxybenzyloxy)-1-methyl-1H-pyrazol-3-yl)phenyl)-N-methylpicolinamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield:

: 1197340-84-3
methyl 3-(4-bromophenyl)-4-(4-methoxybenzyloxy)-1H-pyrazole-5-carboxylate

: 1197340-75-2
5-(4-(5-(2-(2,4-dimethoxybenzyl)-6-(2,4-dimethoxybenzylamino)isoindolin-5-ylcarbamoyl)-4-(4-methoxybenzyloxy)-1-methyl-1H-pyrazol-3-yl)phenyl)-N-methylpicolinamide

Guidance literature:: Multi-step reaction with 4 steps

1: lithium hydroxide monohydrate / N,N-dimethyl-formamide / 3 h / 20 °C / Ice bath

2: potassium carbonate / polyethylene supported palladium catalyst (FibreCat FC 1007) / ethanol; water / 0.25 h / 115 °C / Microwave irradiation

3: lithium hydroxide monohydrate; water / ethanol / 0.33 h / 115 °C / Microwave irradiation

4: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 2 h / 20 °C

With lithium hydroxide monohydrate; water; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; polyethylene supported palladium catalyst (FibreCat FC 1007); In ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 1197340-73-0
methyl 3-(4-bromophenyl)-4-(4-methoxybenzyloxy)-1-methyl-1H-pyrazole-5-carboxylate

: 1197340-75-2
5-(4-(5-(2-(2,4-dimethoxybenzyl)-6-(2,4-dimethoxybenzylamino)isoindolin-5-ylcarbamoyl)-4-(4-methoxybenzyloxy)-1-methyl-1H-pyrazol-3-yl)phenyl)-N-methylpicolinamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / polyethylene supported palladium catalyst (FibreCat FC 1007) / ethanol; water / 0.25 h / 115 °C / Microwave irradiation

2: lithium hydroxide monohydrate; water / ethanol / 0.33 h / 115 °C / Microwave irradiation

3: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 2 h / 20 °C

With lithium hydroxide monohydrate; water; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; polyethylene supported palladium catalyst (FibreCat FC 1007); In ethanol; water; N,N-dimethyl-formamide;