(2R,4S)-4-Benzoylamino-2-hydroxy-2-methyl-pentanedioic acid diethyl ester

Base Information

• Chemical Name: (2R,4S)-4-Benzoylamino-2-hydroxy-2-methyl-pentanedioic acid diethyl ester
• CAS No.: 219843-47-7
• Molecular Formula: C₁₇H₂₃NO₆
• Molecular Weight: 337.373
• Mol file: 219843-47-7.mol

Synonyms:(2R,4S)-4-Benzoylamino-2-hydroxy-2-methyl-pentanedioic acid diethyl ester

Chemical Property of (2R,4S)-4-Benzoylamino-2-hydroxy-2-methyl-pentanedioic acid diethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R,4S)-4-Benzoylamino-2-hydroxy-2-methyl-pentanedioic acid diethyl ester

There total 3 articles about (2R,4S)-4-Benzoylamino-2-hydroxy-2-methyl-pentanedioic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

benzoic acid anhydride (93-97-0) + diethyl (R)-5-methyl-4,5-dihydroisoxazole-3,5-dicarboxylate (141611-41-8) → (2R,4S)-4-Benzoylamino-2-hydroxy-2-methyl-pentanedioic acid diethyl ester (219843-47-7) + (2R,4R)-4-Benzoylamino-2-hydroxy-2-methyl-pentanedioic acid diethyl ester (219843-46-6)

Guidance literature:

With phosphate buffer; hydrogen; nickel; In methanol; under 760 Torr; Ambient temperature;

DOI:10.1016/S0957-4166(98)00372-3

Reference yield:

5-Methyl-4,5-dihydro-isoxazole-3,5-dicarboxylic acid diethyl ester (141562-82-5) → (2R,4S)-4-Benzoylamino-2-hydroxy-2-methyl-pentanedioic acid diethyl ester (219843-47-7)

Guidance literature:

Multi-step reaction with 3 steps

1: Aspergillus oryzae proteaze

2: SOCl₂ / Heating

3: 41 percent / H₂, phosphate buffer / Raney nickel / methanol / 760 Torr / Ambient temperature

With thionyl chloride; phosphate buffer; Aspergillus oryzae proteaze; hydrogen; nickel; In methanol;

DOI:10.1016/S0957-4166(98)00372-3

Reference yield:

(S)-5-Methyl-4,5-dihydro-isoxazole-3,5-dicarboxylic acid 3-ethyl ester (141562-83-6) → (2R,4S)-4-Benzoylamino-2-hydroxy-2-methyl-pentanedioic acid diethyl ester (219843-47-7)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂ / Heating

2: 41 percent / H₂, phosphate buffer / Raney nickel / methanol / 760 Torr / Ambient temperature

With thionyl chloride; phosphate buffer; hydrogen; nickel; In methanol;

DOI:10.1016/S0957-4166(98)00372-3

upstream raw materials:

benzoic acid anhydride

diethyl (R)-5-methyl-4,5-dihydroisoxazole-3,5-dicarboxylate

(S)-5-Methyl-4,5-dihydro-isoxazole-3,5-dicarboxylic acid 3-ethyl ester

5-Methyl-4,5-dihydro-isoxazole-3,5-dicarboxylic acid diethyl ester