5-(2-(4-(3-(4-(dimethylcarbamoyl)phenyl)ureido)phenyl)-4-morpholino-quinazolin-7-yl)furan-2-carboxylic acid

Base Information

• Chemical Name: 5-(2-(4-(3-(4-(dimethylcarbamoyl)phenyl)ureido)phenyl)-4-morpholino-quinazolin-7-yl)furan-2-carboxylic acid
• CAS No.: 1374203-80-1
• Molecular Formula: C₃₃H₃₀N₆O₆
• Molecular Weight: 606.638
• Mol file: 1374203-80-1.mol

Synonyms:5-(2-(4-(3-(4-(dimethylcarbamoyl)phenyl)ureido)phenyl)-4-morpholino-quinazolin-7-yl)furan-2-carboxylic acid

Chemical Property of 5-(2-(4-(3-(4-(dimethylcarbamoyl)phenyl)ureido)phenyl)-4-morpholino-quinazolin-7-yl)furan-2-carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(2-(4-(3-(4-(dimethylcarbamoyl)phenyl)ureido)phenyl)-4-morpholino-quinazolin-7-yl)furan-2-carboxylic acid

There total 13 articles about 5-(2-(4-(3-(4-(dimethylcarbamoyl)phenyl)ureido)phenyl)-4-morpholino-quinazolin-7-yl)furan-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

methyl 5-(2-(4-(3-(4-(dimethylcarbamoyl)phenyl)ureido)phenyl)-4-morpholino-quinazolin-7-yl)furan-2-carboxylate (1374208-57-7) → 5-(2-(4-(3-(4-(dimethylcarbamoyl)phenyl)ureido)phenyl)-4-morpholino-quinazolin-7-yl)furan-2-carboxylic acid (1374203-80-1)

Guidance literature:

methyl 5-(2-(4-(3-(4-(dimethylcarbamoyl)phenyl)ureido)phenyl)-4-morpholino-quinazolin-7-yl)furan-2-carboxylate; With lithium hydroxide monohydrate; In tetrahydrofuran; methanol; water; at 20 ℃; for 12h;

With hydrogenchloride; pH=5;

Reference yield:

m-Bromoaniline (591-19-5) → 5-(2-(4-(3-(4-(dimethylcarbamoyl)phenyl)ureido)phenyl)-4-morpholino-quinazolin-7-yl)furan-2-carboxylic acid (1374203-80-1)

Guidance literature:

Multi-step reaction with 10 steps

1.1: hydroxylamine hydrochloride; sodium sulfate; 1-[4-(4-methyl-piperazine-1-carbonyl)-phenyl]-3-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-urea / 2 h / 90 °C

2.1: sulfuric acid / 3 h / 90 °C

3.1: sodium hydroxide; dihydrogen peroxide / water / 2 h / 0 °C

3.2: 0 °C / pH 6

4.1: 3 h / 195 °C

5.1: N-ethyl-N,N-diisopropylamine; trichlorophosphate / 12 h / 130 °C

6.1: dichloromethane / 0.5 h / 0 °C

7.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / toluene; ethanol; water / 2.83 h / 75 °C / Inert atmosphere

8.1: manganese(IV) oxide; sodium cyanide / methanol / 3 h / 0 - 25 °C

9.1: caesium carbonate / bis-triphenylphosphine-palladium(II) chloride / toluene; ethanol / 3.33 h / 75 °C / Inert atmosphere

10.1: lithium hydroxide monohydrate / water; tetrahydrofuran; methanol / 12 h / 20 °C

10.2: pH 5

With sodium cyanide; manganese(IV) oxide; lithium hydroxide monohydrate; sulfuric acid; 1-[4-(4-methyl-piperazine-1-carbonyl)-phenyl]-3-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-urea; hydroxylamine hydrochloride; dihydrogen peroxide; sodium carbonate; caesium carbonate; sodium sulfate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; trichlorophosphate; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; toluene;

Reference yield:

7-bromoquinazoline-2,4(1H,3H)-dione (114703-12-7) → 5-(2-(4-(3-(4-(dimethylcarbamoyl)phenyl)ureido)phenyl)-4-morpholino-quinazolin-7-yl)furan-2-carboxylic acid (1374203-80-1)

Guidance literature:

Multi-step reaction with 6 steps

1.1: N-ethyl-N,N-diisopropylamine; trichlorophosphate / 12 h / 130 °C

2.1: dichloromethane / 0.5 h / 0 °C

3.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / toluene; ethanol; water / 2.83 h / 75 °C / Inert atmosphere

4.1: manganese(IV) oxide; sodium cyanide / methanol / 3 h / 0 - 25 °C

5.1: caesium carbonate / bis-triphenylphosphine-palladium(II) chloride / toluene; ethanol / 3.33 h / 75 °C / Inert atmosphere

6.1: lithium hydroxide monohydrate / water; tetrahydrofuran; methanol / 12 h / 20 °C

6.2: pH 5

With sodium cyanide; manganese(IV) oxide; lithium hydroxide monohydrate; sodium carbonate; caesium carbonate; N-ethyl-N,N-diisopropylamine; trichlorophosphate; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; toluene;

upstream raw materials:

m-Bromoaniline

7-bromoquinazoline-2,4(1H,3H)-dione

6-bromoisatin

N-(3-bromophenyl)-2-(hydroxyimino)ethanamide