rac-4,4'-((1R,2R,3S,4S)-2,4-di-m-tolylcyclobutane-1,3-diyl)dipyridine

Base Information

• Chemical Name: rac-4,4'-((1R,2R,3S,4S)-2,4-di-m-tolylcyclobutane-1,3-diyl)dipyridine
• CAS No.: 1334400-12-2
• Molecular Formula: C₂₈H₂₆N₂
• Molecular Weight: 390.528
• Mol file: 1334400-12-2.mol

Synonyms:rac-4,4'-((1R,2R,3S,4S)-2,4-di-m-tolylcyclobutane-1,3-diyl)dipyridine

Chemical Property of rac-4,4'-((1R,2R,3S,4S)-2,4-di-m-tolylcyclobutane-1,3-diyl)dipyridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of rac-4,4'-((1R,2R,3S,4S)-2,4-di-m-tolylcyclobutane-1,3-diyl)dipyridine

There total 4 articles about rac-4,4'-((1R,2R,3S,4S)-2,4-di-m-tolylcyclobutane-1,3-diyl)dipyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2C14H8O5(2-)*2Zn(2+)*C28H26N2*0.25C14H13N → rac-4,4'-((1R,2R,3S,4S)-2,4-di-m-tolylcyclobutane-1,3-diyl)dipyridine (1334400-12-2)

Guidance literature:

With nitric acid; In water; for 0.166667h;

DOI:10.1002/anie.201806076

Reference yield: 92.0%

4-(3-methylstyryl)pyridine → rac-4,4'-((1R,2R,3S,4S)-2,4-di-m-tolylcyclobutane-1,3-diyl)dipyridine (1334400-12-2)

Guidance literature:

With oxalic acid; In cyclohexane; at 35 ℃; for 16h; stereoselective reaction; UV-irradiation;

DOI:10.1002/chem.201905597

Reference yield: 57.0%

(E)-4-(3-methylstyryl)pyridine (5825-19-4,7372-08-9,31338-29-1) → cis-3'-Methyl-4-stilbazol (7372-08-9,31338-29-1,5825-19-4) + rac-4,4'-((1R,2R,3S,4S)-2,4-di-m-tolylcyclobutane-1,3-diyl)dipyridine (1334400-12-2) + C28H26N2 (1365995-10-3) + C28H26N2 (1365995-09-0)

Guidance literature:

With hydrogenchloride; In methanol; regiospecific reaction; Irradiation;

DOI:10.1039/c1pp05079f

upstream raw materials:

(E)-4-(3-methylstyryl)pyridine

picoline

m-tolyl aldehyde