ethyl 3-(5-amino-2-{2-[4-(2-{2-[2-(diethoxyphosphoryl)ethoxy]ethoxy}ethoxy)-2-methylphenyl]ethyl}benzo[f][1,7]naphthyridin-8-yl)propanoate

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Chemical Name:ethyl 3-(5-amino-2-{2-[4-(2-{2-[2-(diethoxyphosphoryl)ethoxy]ethoxy}ethoxy)-2-methylphenyl]ethyl}benzo[f][1,7]naphthyridin-8-yl)propanoate
CAS No.:1268527-10-1
Molecular Formula:C₃₆H₄₈N₃O₈P
Molecular Weight:681.766
Hs Code.:

Synonyms:ethyl 3-(5-amino-2-{2-[4-(2-{2-[2-(diethoxyphosphoryl)ethoxy]ethoxy}ethoxy)-2-methylphenyl]ethyl}benzo[f][1,7]naphthyridin-8-yl)propanoate

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Chemical Property of ethyl 3-(5-amino-2-{2-[4-(2-{2-[2-(diethoxyphosphoryl)ethoxy]ethoxy}ethoxy)-2-methylphenyl]ethyl}benzo[f][1,7]naphthyridin-8-yl)propanoate

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Technology Process of ethyl 3-(5-amino-2-{2-[4-(2-{2-[2-(diethoxyphosphoryl)ethoxy]ethoxy}ethoxy)-2-methylphenyl]ethyl}benzo[f][1,7]naphthyridin-8-yl)propanoate

There total 14 articles about ethyl 3-(5-amino-2-{2-[4-(2-{2-[2-(diethoxyphosphoryl)ethoxy]ethoxy}ethoxy)-2-methylphenyl]ethyl}benzo[f][1,7]naphthyridin-8-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 14472-14-1
4-bromo-3-methylphenol

: 1268527-10-1
ethyl 3-(5-amino-2-{2-[4-(2-{2-[2-(diethoxyphosphoryl)ethoxy]ethoxy}ethoxy)-2-methylphenyl]ethyl}benzo[f][1,7]naphthyridin-8-yl)propanoate

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C

1.2: 3.5 h / 20 °C

2.1: triethylamine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 60 °C / Inert atmosphere

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 20 °C

4.1: triethylamine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 60 °C / Inert atmosphere

5.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; sodium hydrogencarbonate / butan-1-ol; water / 100 °C

6.1: palladium 10% on activated carbon; hydrogen / ethanol; tetrahydrofuran / 24 h

7.1: hydrogenchloride / ethanol; 1,4-dioxane / 3 h

8.1: caesium carbonate / N,N-dimethyl-formamide / 1.5 h / 60 °C

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(l) iodide; palladium 10% on activated carbon; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; sodium hydrogencarbonate; caesium carbonate; triethylamine; XPhos; In tetrahydrofuran; 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide; butan-1-ol;

Reference yield:

: 1258595-04-8
3-chloro-5-((4-(methoxymethoxy)-2-methylphenyl)ethynyl)picolinonitrile

: 1268527-10-1
ethyl 3-(5-amino-2-{2-[4-(2-{2-[2-(diethoxyphosphoryl)ethoxy]ethoxy}ethoxy)-2-methylphenyl]ethyl}benzo[f][1,7]naphthyridin-8-yl)propanoate

Guidance literature:: Multi-step reaction with 4 steps

1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; sodium hydrogencarbonate / butan-1-ol; water / 100 °C

2: palladium 10% on activated carbon; hydrogen / ethanol; tetrahydrofuran / 24 h

3: hydrogenchloride / ethanol; 1,4-dioxane / 3 h

4: caesium carbonate / N,N-dimethyl-formamide / 1.5 h / 60 °C

With hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; sodium hydrogencarbonate; caesium carbonate; XPhos; In tetrahydrofuran; 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide; butan-1-ol;

Reference yield:

: 1258595-02-6
triethyl((4-(methoxymethoxy)-2-methylphenyl)ethynyl)silane

: 1268527-10-1
ethyl 3-(5-amino-2-{2-[4-(2-{2-[2-(diethoxyphosphoryl)ethoxy]ethoxy}ethoxy)-2-methylphenyl]ethyl}benzo[f][1,7]naphthyridin-8-yl)propanoate

Guidance literature:: Multi-step reaction with 6 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 20 °C

2: triethylamine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 60 °C / Inert atmosphere

3: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; sodium hydrogencarbonate / butan-1-ol; water / 100 °C

4: palladium 10% on activated carbon; hydrogen / ethanol; tetrahydrofuran / 24 h

5: hydrogenchloride / ethanol; 1,4-dioxane / 3 h

6: caesium carbonate / N,N-dimethyl-formamide / 1.5 h / 60 °C

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(l) iodide; palladium 10% on activated carbon; tetrabutyl ammonium fluoride; hydrogen; sodium hydrogencarbonate; caesium carbonate; triethylamine; XPhos; In tetrahydrofuran; 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide; butan-1-ol;