tert-Butyl-[(1R,6S,7S,8R)-8-(1-ethoxy-ethoxymethyl)-9-oxa-bicyclo[4.2.1]nona-2,4-dien-7-ylmethoxy]-diphenyl-silane

Base Information

Chemical Name:tert-Butyl-[(1R,6S,7S,8R)-8-(1-ethoxy-ethoxymethyl)-9-oxa-bicyclo[4.2.1]nona-2,4-dien-7-ylmethoxy]-diphenyl-silane
CAS No.:817201-23-3
Molecular Formula:C₃₀H₄₀O₄Si
Molecular Weight:492.731
Hs Code.:

Synonyms:tert-Butyl-[(1R,6S,7S,8R)-8-(1-ethoxy-ethoxymethyl)-9-oxa-bicyclo[4.2.1]nona-2,4-dien-7-ylmethoxy]-diphenyl-silane

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Chemical Property of tert-Butyl-[(1R,6S,7S,8R)-8-(1-ethoxy-ethoxymethyl)-9-oxa-bicyclo[4.2.1]nona-2,4-dien-7-ylmethoxy]-diphenyl-silane

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Technology Process of tert-Butyl-[(1R,6S,7S,8R)-8-(1-ethoxy-ethoxymethyl)-9-oxa-bicyclo[4.2.1]nona-2,4-dien-7-ylmethoxy]-diphenyl-silane

There total 3 articles about tert-Butyl-[(1R,6S,7S,8R)-8-(1-ethoxy-ethoxymethyl)-9-oxa-bicyclo[4.2.1]nona-2,4-dien-7-ylmethoxy]-diphenyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 817201-09-5
(1S,2S,3R,4R)-2-(tert-butyldiphenylsilyloxy)methyl-3-(1-ethoxyethoxy)methyl-7-oxabicyclo[2.2.1]hept-5-ene

: 106-99-0,130983-70-9,29406-96-0,9003-17-2
buta-1,3-diene

: 817201-23-3
tert-Butyl-[(1R,6S,7S,8R)-8-(1-ethoxy-ethoxymethyl)-9-oxa-bicyclo[4.2.1]nona-2,4-dien-7-ylmethoxy]-diphenyl-silane

Guidance literature:: (1S,2S,3R,4R)-2-(tert-butyldiphenylsilyloxy)methyl-3-(1-ethoxyethoxy)methyl-7-oxabicyclo[2.2.1]hept-5-ene; buta-1,3-diene; With Grubbs catalyst first generation; buta-1,3-diene; In benzene; at 20 ℃; for 0.5h;

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In benzene; for 48h; Heating;
DOI:10.1021/jo048566j

Reference yield:

: 817201-08-4
(1R,2R,3S,4S)-2-(1-ethoxyethoxy)methyl-3-hydroxymethyl-7-oxabicyclo[2.2.1]hept-5-ene

: 817201-23-3
tert-Butyl-[(1R,6S,7S,8R)-8-(1-ethoxy-ethoxymethyl)-9-oxa-bicyclo[4.2.1]nona-2,4-dien-7-ylmethoxy]-diphenyl-silane

Guidance literature:: Multi-step reaction with 2 steps

1.1: imidazole / dimethylformamide / 23 h / 0 °C

2.1: (PCy₃)2Cl₂Ru=CHPh; 1,3-butadiene / benzene / 0.5 h / 20 °C

2.2: [1,3-dimesitylimidazolidin-2-yl]Cl₂(PCy₃)Ru=CHPh / benzene / 48 h / Heating

With 1H-imidazole; Grubbs catalyst first generation; buta-1,3-diene; In N,N-dimethyl-formamide; benzene;
DOI:10.1021/jo048566j

Reference yield:

: 817201-07-3
(1S,2S,3R,4R)-2-acetoxymethyl-3-(1-ethoxyethoxy)methyl-7-oxabicyclo[2.2.1]hept-5-ene

: 817201-23-3
tert-Butyl-[(1R,6S,7S,8R)-8-(1-ethoxy-ethoxymethyl)-9-oxa-bicyclo[4.2.1]nona-2,4-dien-7-ylmethoxy]-diphenyl-silane

Guidance literature:: Multi-step reaction with 3 steps

1.1: 100 percent / NaOMe / methanol / 2 h / 20 °C

2.1: imidazole / dimethylformamide / 23 h / 0 °C

3.1: (PCy₃)2Cl₂Ru=CHPh; 1,3-butadiene / benzene / 0.5 h / 20 °C

3.2: [1,3-dimesitylimidazolidin-2-yl]Cl₂(PCy₃)Ru=CHPh / benzene / 48 h / Heating

With 1H-imidazole; Grubbs catalyst first generation; sodium methylate; buta-1,3-diene; In methanol; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jo048566j