2-(3-Methoxyphenyl)pyridin-3-ol

Base Information

Chemical Name:2-(3-Methoxyphenyl)pyridin-3-ol
CAS No.:857436-14-7
Molecular Formula:C₁₂H₁₁NO₂
Molecular Weight:201.225
Hs Code.:
DSSTox Substance ID:DTXSID30682616
Nikkaji Number:J3.535.893E
Wikidata:Q82607064

Synonyms:2-(3-methoxyphenyl)pyridin-3-ol;3-HYDROXY-2-(3-METHOXYPHENYL)PYRIDINE;857436-14-7;DTXSID30682616;2-(3-Methoxyphenyl)pyridine-3-ol;MFCD18312002;AKOS017558089;J3.535.893E;A1-28815

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(3-Methoxyphenyl)pyridin-3-ol

Chemical Property:

XLogP3:2.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:201.078978594
Heavy Atom Count:15
Complexity:198

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=CC=CC(=C1)C2=C(C=CC=N2)O

Technology Process of 2-(3-Methoxyphenyl)pyridin-3-ol

There total 4 articles about 2-(3-Methoxyphenyl)pyridin-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: C₁₄H₁₅NO₃

: 857436-14-7
2-(3-methoxyphenyl)pyridin-3-ol

Guidance literature:: C₁₄H₁₅NO₃; With hydrogenchloride; In tetrahydrofuran; ethanol; water; at 60 ℃; for 2h;

With sodium hydrogencarbonate; In tetrahydrofuran; ethanol; water;
DOI:10.1021/acs.orglett.5b00276

Reference yield: 40.0%

: 109-00-2
3-HYDROXYPYRIDINE

: 536-90-3,918666-97-4
m-Anisidine

: 857436-14-7
2-(3-methoxyphenyl)pyridin-3-ol

Guidance literature:: m-Anisidine; With hydrogenchloride; sodium nitrite; In water; at 0 ℃; for 0.5h;

3-HYDROXYPYRIDINE; With hydrogenchloride; titanium(III) chloride; In water; for 0.416667h; regioselective reaction; Inert atmosphere;
DOI:10.1021/acs.joc.6b00894

Reference yield:

: 10365-98-7,1107579-37-2
3-methoxyphenylboronic acid

: 857436-14-7
2-(3-methoxyphenyl)pyridin-3-ol

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium fluoride dihydrate / toluene; water / 90 °C

2: hydrogenchloride / water; tetrahydrofuran; ethanol / 2 h / 60 °C

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium fluoride dihydrate; In tetrahydrofuran; ethanol; water; toluene;
DOI:10.1021/acs.orglett.5b00276