benzyl 4-({6-[(tert-butoxycarbonyl)(methyl)amino]pyridin-2-yl}methyl)piperidine-1-carboxylate

Base Information

Chemical Name:benzyl 4-({6-[(tert-butoxycarbonyl)(methyl)amino]pyridin-2-yl}methyl)piperidine-1-carboxylate
CAS No.:959991-97-0
Molecular Formula:C₂₅H₃₃N₃O₄
Molecular Weight:439.555
Hs Code.:

Synonyms:benzyl 4-({6-[(tert-butoxycarbonyl)(methyl)amino]pyridin-2-yl}methyl)piperidine-1-carboxylate

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Chemical Property of benzyl 4-({6-[(tert-butoxycarbonyl)(methyl)amino]pyridin-2-yl}methyl)piperidine-1-carboxylate

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Technology Process of benzyl 4-({6-[(tert-butoxycarbonyl)(methyl)amino]pyridin-2-yl}methyl)piperidine-1-carboxylate

There total 1 articles about benzyl 4-({6-[(tert-butoxycarbonyl)(methyl)amino]pyridin-2-yl}methyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 74-88-4
methyl iodide

: 959991-97-0
benzyl 4-({6-[(tert-butoxycarbonyl)(methyl)amino]pyridin-2-yl}methyl)piperidine-1-carboxylate

Guidance literature:: benzyl 4-({6-[(tert-butoxycarbonyl)amino]pyridin-2-yl}methyl)piperidine-1-carboxylate; With sodium hydride; at 0 ℃; for 0.25h;

methyl iodide; at 20 ℃; for 20h;

Reference yield:

: 959991-97-0
benzyl 4-({6-[(tert-butoxycarbonyl)(methyl)amino]pyridin-2-yl}methyl)piperidine-1-carboxylate

: N-(2,6-dichlorobenzoyl)-4-(4-{[6-(methylamino)pyridin-2-yl]methyl}piperidin-1-yl)-L-phenylalanine

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen / palladium 10% on activated carbon / ethanol / 1.5 h / 2068.65 Torr

2: copper(l) iodide; caesium carbonate; L-proline / dimethyl sulfoxide / 18 h / 90 °C

3: trifluoroacetic acid / 2 h / 20 °C

4: lithium hydroxide; water / N,N-dimethyl acetamide / 3 h / 20 °C

With lithium hydroxide; copper(l) iodide; water; hydrogen; caesium carbonate; trifluoroacetic acid; L-proline; palladium 10% on activated carbon; In ethanol; N,N-dimethyl acetamide; dimethyl sulfoxide;

Reference yield:

: 959991-97-0
benzyl 4-({6-[(tert-butoxycarbonyl)(methyl)amino]pyridin-2-yl}methyl)piperidine-1-carboxylate

: methyl N-(2,6-dichlorobenzoyl)-4-(4-{[6-(methylamino)pyridin-2-yl]methyl}piperidin-1-yl)-L-phenylalaninate

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen / palladium 10% on activated carbon / ethanol / 1.5 h / 2068.65 Torr

2: copper(l) iodide; caesium carbonate; L-proline / dimethyl sulfoxide / 18 h / 90 °C

3: trifluoroacetic acid / 2 h / 20 °C

With copper(l) iodide; hydrogen; caesium carbonate; trifluoroacetic acid; L-proline; palladium 10% on activated carbon; In ethanol; dimethyl sulfoxide;