N-(2-bromo-5-methylphenyl)-N-methyl-2-fluoro-2-(4-methylphenyl)acetamide

Base Information

Chemical Name:N-(2-bromo-5-methylphenyl)-N-methyl-2-fluoro-2-(4-methylphenyl)acetamide
CAS No.:1379665-13-0
Molecular Formula:C₁₇H₁₇BrFNO
Molecular Weight:350.23
Hs Code.:

Synonyms:N-(2-bromo-5-methylphenyl)-N-methyl-2-fluoro-2-(4-methylphenyl)acetamide

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Chemical Property of N-(2-bromo-5-methylphenyl)-N-methyl-2-fluoro-2-(4-methylphenyl)acetamide

Chemical Property:

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Technology Process of N-(2-bromo-5-methylphenyl)-N-methyl-2-fluoro-2-(4-methylphenyl)acetamide

There total 3 articles about N-(2-bromo-5-methylphenyl)-N-methyl-2-fluoro-2-(4-methylphenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1379664-96-6
C₁₆H₁₅BrFNO

: 74-88-4
methyl iodide

: 1379665-13-0
N-(2-bromo-5-methylphenyl)-N-methyl-2-fluoro-2-(4-methylphenyl)acetamide

Guidance literature:: C₁₆H₁₅BrFNO; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 ℃; for 0.5h; Inert atmosphere;

methyl iodide; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1002/anie.201200206

Reference yield:

2-bromo-p-toluidine: 583-68-6
2-bromo-p-toluidine

: 1379665-13-0
N-(2-bromo-5-methylphenyl)-N-methyl-2-fluoro-2-(4-methylphenyl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 0 - 20 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C / Inert atmosphere

2.2: 0 - 20 °C / Inert atmosphere

With dmap; sodium hydride; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; mineral oil;
DOI:10.1002/anie.201200206

Reference yield:

: 142012-67-7,175845-89-3
2-fluoro-2-p-methylphenylethanoic acid

: 1379665-13-0
N-(2-bromo-5-methylphenyl)-N-methyl-2-fluoro-2-(4-methylphenyl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 0 - 20 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C / Inert atmosphere

2.2: 0 - 20 °C / Inert atmosphere

With dmap; sodium hydride; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; mineral oil;
DOI:10.1002/anie.201200206