(R)-tert-butyl 6-(2-(tert-butoxycarbonyl-(2-(3-(2-fluorophenylsulfonamide)phenyl)-2-(triethylsilyloxy)ethyl)amino)ethoxy)-3-methylindazole-1-carboyxlate

Base Information

Chemical Name:(R)-tert-butyl 6-(2-(tert-butoxycarbonyl-(2-(3-(2-fluorophenylsulfonamide)phenyl)-2-(triethylsilyloxy)ethyl)amino)ethoxy)-3-methylindazole-1-carboyxlate
CAS No.:1283128-39-1
Molecular Formula:C₄₀H₅₅FN₄O₈SSi
Molecular Weight:799.049
Hs Code.:

(R)-tert-butyl 6-(2-(tert-butoxycarbonyl-(2-(3-(2-fluorophenylsulfonamide)phenyl)-2-(triethylsilyloxy)ethyl)amino)ethoxy)-3-methylindazole-1-carboyxlate

Synonyms:(R)-tert-butyl 6-(2-(tert-butoxycarbonyl-(2-(3-(2-fluorophenylsulfonamide)phenyl)-2-(triethylsilyloxy)ethyl)amino)ethoxy)-3-methylindazole-1-carboyxlate

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Chemical Property of (R)-tert-butyl 6-(2-(tert-butoxycarbonyl-(2-(3-(2-fluorophenylsulfonamide)phenyl)-2-(triethylsilyloxy)ethyl)amino)ethoxy)-3-methylindazole-1-carboyxlate

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Technology Process of (R)-tert-butyl 6-(2-(tert-butoxycarbonyl-(2-(3-(2-fluorophenylsulfonamide)phenyl)-2-(triethylsilyloxy)ethyl)amino)ethoxy)-3-methylindazole-1-carboyxlate

There total 8 articles about (R)-tert-butyl 6-(2-(tert-butoxycarbonyl-(2-(3-(2-fluorophenylsulfonamide)phenyl)-2-(triethylsilyloxy)ethyl)amino)ethoxy)-3-methylindazole-1-carboyxlate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1221179-29-8
tert-butyl (R)-6-[2-[N-((2-(3-aminophenyl)-2-((triethylsilyl)oxy)ethyl)-N-(tert-butoxycarbonyl)amino)]ethoxy]-3-methyl-1H-indazole-1-carboxylate

: 2905-21-7
2-fluorobenzenesulfonyl chloride

: 1283128-39-1
(R)-tert-butyl 6-(2-(tert-butoxycarbonyl-(2-(3-(2-fluorophenylsulfonamide)phenyl)-2-(triethylsilyloxy)ethyl)amino)ethoxy)-3-methylindazole-1-carboyxlate

Guidance literature:: With pyridine; In dichloromethane; at 20 ℃;

Reference yield:

: 201286-99-9
3-methyl-1H-indazol-6-ol

: 1283128-39-1
(R)-tert-butyl 6-(2-(tert-butoxycarbonyl-(2-(3-(2-fluorophenylsulfonamide)phenyl)-2-(triethylsilyloxy)ethyl)amino)ethoxy)-3-methylindazole-1-carboyxlate

Guidance literature:: Multi-step reaction with 5 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 20 °C

2: triethylamine / dmap / dichloromethane / 20 °C

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

4: triphenylphosphine; di-isopropyl azodicarboxylate / toluene / 20 °C

5: pyridine / dichloromethane / 20 °C

With pyridine; 1H-imidazole; di-isopropyl azodicarboxylate; tetrabutyl ammonium fluoride; triethylamine; triphenylphosphine; dmap; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 519158-44-2
1-benzyl-3-methyl-1H-indazol-6-ol

: 1283128-39-1
(R)-tert-butyl 6-(2-(tert-butoxycarbonyl-(2-(3-(2-fluorophenylsulfonamide)phenyl)-2-(triethylsilyloxy)ethyl)amino)ethoxy)-3-methylindazole-1-carboyxlate

Guidance literature:: Multi-step reaction with 6 steps

1: hydrogenchloride; hydrogen / palladium 10% on activated carbon / ethanol; water / 15 h / 60 °C / Inert atmosphere

2: 1H-imidazole / N,N-dimethyl-formamide / 20 °C

3: triethylamine / dmap / dichloromethane / 20 °C

4: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

5: triphenylphosphine; di-isopropyl azodicarboxylate / toluene / 20 °C

6: pyridine / dichloromethane / 20 °C

With pyridine; 1H-imidazole; hydrogenchloride; di-isopropyl azodicarboxylate; tetrabutyl ammonium fluoride; hydrogen; triethylamine; triphenylphosphine; dmap; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;