3-(5'-O-benzoyl-2',3'-isopropylidene-β-D-ribofuranos-1'-yl)-5-ethoxycarbonyl-4,5-dihydroisoxazole

Base Information

• Chemical Name: 3-(5'-O-benzoyl-2',3'-isopropylidene-β-D-ribofuranos-1'-yl)-5-ethoxycarbonyl-4,5-dihydroisoxazole
• CAS No.: 165878-01-3
• Molecular Formula: C₂₁H₂₅NO₈
• Molecular Weight: 419.431
• Mol file: 165878-01-3.mol

Synonyms:3-(5'-O-benzoyl-2',3'-isopropylidene-β-D-ribofuranos-1'-yl)-5-ethoxycarbonyl-4,5-dihydroisoxazole

Chemical Property of 3-(5'-O-benzoyl-2',3'-isopropylidene-β-D-ribofuranos-1'-yl)-5-ethoxycarbonyl-4,5-dihydroisoxazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 3-(5'-O-benzoyl-2',3'-isopropylidene-β-D-ribofuranos-1'-yl)-5-ethoxycarbonyl-4,5-dihydroisoxazole

There total 1 articles about 3-(5'-O-benzoyl-2',3'-isopropylidene-β-D-ribofuranos-1'-yl)-5-ethoxycarbonyl-4,5-dihydroisoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

2,5-anhydro-6-O-benzoyl-1-deoxy-3,4-O-isopropylidene-1-nitro-D-allitol (65982-25-4) + ethyl acrylate (140-88-5,9003-32-1) → 3-(5'-O-benzoyl-2',3'-isopropylidene-β-D-ribofuranos-1'-yl)-5-ethoxycarbonyl-4,5-dihydroisoxazole (165878-01-3)

Guidance literature:

With phenyl isocyanate; triethylamine; In benzene; Ambient temperature;

DOI:10.1055/s-1994-25663

Reference yield: 86.0%

3-(5'-O-benzoyl-2',3'-isopropylidene-β-D-ribofuranos-1'-yl)-5-ethoxycarbonyl-4,5-dihydroisoxazole (165878-01-3) → ethyl 4-(5'-O-benzoyl-2',3'-isopropylidene-β-D-ribofuranos-1'-yl)-2-hydroxy-4-oxobutenoate (165878-02-4)

Guidance literature:

With molybdenum hexacarbonyl; In water; acetonitrile; Heating;

DOI:10.1055/s-1994-25663

Reference yield:

3-(5'-O-benzoyl-2',3'-isopropylidene-β-D-ribofuranos-1'-yl)-5-ethoxycarbonyl-4,5-dihydroisoxazole (165878-01-3) → 6-(5'-O-benzoyl-β-D-ribofuranos-1'-yl)pyridazin-3(2H)-one (160427-29-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 86 percent / molybdenum hexacarbonyl / acetonitrile; H₂O / Heating

2: 98 percent / 99percent hydrazine hydrate / ethanol / 3 h / Heating

With molybdenum hexacarbonyl; hydrazine hydrate; In ethanol; water; acetonitrile;

DOI:10.1055/s-1994-25663

upstream raw materials:

2,5-anhydro-6-O-benzoyl-1-deoxy-3,4-O-isopropylidene-1-nitro-D-allitol

ethyl acrylate

Downstream raw materials:

ethyl 4-(5'-O-benzoyl-2',3'-isopropylidene-β-D-ribofuranos-1'-yl)-2-hydroxy-4-oxobutenoate

6-(5'-O-benzoyl-β-D-ribofuranos-1'-yl)pyridazin-3(2H)-one