methyl 4-[(4-methoxyphenyl)sulfonyl]-2,2-dimethyl-3(S)-thiomorpholinecarboxylate

Base Information

Chemical Name:methyl 4-[(4-methoxyphenyl)sulfonyl]-2,2-dimethyl-3(S)-thiomorpholinecarboxylate
CAS No.:204141-31-1
Molecular Formula:C₁₅H₂₁NO₅S₂
Molecular Weight:359.467
Hs Code.:

Synonyms:methyl 4-[(4-methoxyphenyl)sulfonyl]-2,2-dimethyl-3(S)-thiomorpholinecarboxylate

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Chemical Property of methyl 4-[(4-methoxyphenyl)sulfonyl]-2,2-dimethyl-3(S)-thiomorpholinecarboxylate

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Technology Process of methyl 4-[(4-methoxyphenyl)sulfonyl]-2,2-dimethyl-3(S)-thiomorpholinecarboxylate

There total 4 articles about methyl 4-[(4-methoxyphenyl)sulfonyl]-2,2-dimethyl-3(S)-thiomorpholinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 204141-30-0
methyl N-[(4-methoxyphenyl)sulfonyl]-S-(2-hydroxyethyl)-D-penicillamine

: 204141-31-1
methyl 4-[(4-methoxyphenyl)sulfonyl]-2,2-dimethyl-3(S)-thiomorpholinecarboxylate

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 20 ℃; for 2h;
DOI:10.1021/jm990330y

Reference yield:

: 34297-27-3
D-penicillamine methyl ester hydrochloride

: 204141-31-1
methyl 4-[(4-methoxyphenyl)sulfonyl]-2,2-dimethyl-3(S)-thiomorpholinecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dimethylformamide / 20 °C

2: Et₃N / dioxane; H₂O / 18 h / 20 °C

3: Ph₃P; diethyl azodicarboxylate / tetrahydrofuran / 2 h / 20 °C

With 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide; 1: Alkylation / 2: sulfonylation / 3: Cyclization;
DOI:10.1021/jm990330y

Reference yield:

: 98-68-0
4-methoxy-phenyl-sulphonyl chloride

: 204141-31-1
methyl 4-[(4-methoxyphenyl)sulfonyl]-2,2-dimethyl-3(S)-thiomorpholinecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N / dioxane; H₂O / 18 h / 20 °C

2: Ph₃P; diethyl azodicarboxylate / tetrahydrofuran / 2 h / 20 °C

With triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; water; 1: sulfonylation / 2: Cyclization;
DOI:10.1021/jm990330y