α-<(tert-Butyldimethylsilyl)oxy>-α-(3,4,5-trimethoxyphenyl)acetonitrile

Base Information

• Chemical Name: α-<(tert-Butyldimethylsilyl)oxy>-α-(3,4,5-trimethoxyphenyl)acetonitrile
• CAS No.: 88488-65-7
• Molecular Formula: C₁₇H₂₇NO₄Si
• Molecular Weight: 337.491

Synonyms:α-<(tert-Butyldimethylsilyl)oxy>-α-(3,4,5-trimethoxyphenyl)acetonitrile

Chemical Property of α-<(tert-Butyldimethylsilyl)oxy>-α-(3,4,5-trimethoxyphenyl)acetonitrile

Chemical Property:

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Technology Process of α-<(tert-Butyldimethylsilyl)oxy>-α-(3,4,5-trimethoxyphenyl)acetonitrile

There total 2 articles about α-<(tert-Butyldimethylsilyl)oxy>-α-(3,4,5-trimethoxyphenyl)acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

3,4,5-trimethoxy-benzaldehyde (86-81-7) + tert-butyldimethylsilyl chloride (18162-48-6) + zinc(II) iodide (10139-47-6) → α-<(tert-Butyldimethylsilyl)oxy>-α-(3,4,5-trimethoxyphenyl)acetonitrile (88488-65-7)

Guidance literature:

With phosphorus pentaoxide; In diethyl ether; ethyl acetate; acetonitrile;

Reference yield: 66.0%

potassium cyanide (151-50-8) + 3,4,5-trimethoxy-benzaldehyde (86-81-7) + tert-butyldimethylsilyl chloride (18162-48-6) → α-<(tert-Butyldimethylsilyl)oxy>-α-(3,4,5-trimethoxyphenyl)acetonitrile (88488-65-7)

Guidance literature:

With zinc(II) iodide; In acetonitrile; for 24h; Ambient temperature;

DOI:10.1021/jo00119a041

Reference yield: 85.0%

α-<(tert-Butyldimethylsilyl)oxy>-α-(3,4,5-trimethoxyphenyl)acetonitrile (88488-65-7) → (tert-Butyl-dimethyl-silanyloxy)-(3,4,5-trimethoxy-phenyl)-acetaldehyde (88488-64-6)

Guidance literature:

With diisobutylaluminium hydride; In dichloromethane; at -78 ℃; for 2h;

upstream raw materials:

potassium cyanide

3,4,5-trimethoxy-benzaldehyde

tert-butyldimethylsilyl chloride

zinc(II) iodide

Downstream raw materials:

(tert-Butyl-dimethyl-silanyloxy)-(3,4,5-trimethoxy-phenyl)-acetaldehyde

dimethyl 1-(3,4-dimethoxyphenyl)-6,7,8-trimethoxynaphthalene-2,3-dicarboxylate

2-[(tert-Butyl-dimethyl-silanyloxy)-cyano-(3,4,5-trimethoxy-phenyl)-methyl]-3-[(3,4-dimethoxy-phenyl)-hydroxy-methyl]-succinic acid dimethyl ester

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