4-(3,4-dichlorophenyl)-6-fluoro-7-(pyridin-2-yl)-1,2,3,4-tetrahydroisoquinoline

Base Information

Chemical Name:4-(3,4-dichlorophenyl)-6-fluoro-7-(pyridin-2-yl)-1,2,3,4-tetrahydroisoquinoline
CAS No.:1255924-32-3
Molecular Formula:C₂₀H₁₅Cl₂FN₂
Molecular Weight:373.257
Hs Code.:

Synonyms:4-(3,4-dichlorophenyl)-6-fluoro-7-(pyridin-2-yl)-1,2,3,4-tetrahydroisoquinoline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(3,4-dichlorophenyl)-6-fluoro-7-(pyridin-2-yl)-1,2,3,4-tetrahydroisoquinoline

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of 4-(3,4-dichlorophenyl)-6-fluoro-7-(pyridin-2-yl)-1,2,3,4-tetrahydroisoquinoline

There total 10 articles about 4-(3,4-dichlorophenyl)-6-fluoro-7-(pyridin-2-yl)-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₃H₁₈Cl₃FN₂O₂

: 1255924-32-3
4-(3,4-dichlorophenyl)-6-fluoro-7-(pyridin-2-yl)-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: With methanol; for 1h; Reflux;

Reference yield:

: 109-04-6
2-bromo-pyridine

: 1255924-32-3
4-(3,4-dichlorophenyl)-6-fluoro-7-(pyridin-2-yl)-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; N,N-dimethyl-formamide / 2.5 h / 90 °C / Inert atmosphere

2: N,N,N',N'-tetramethyl-1,8-diaminonaphthalene / 1,2-dichloro-ethane / Reflux

3: methanol / 1 h / Reflux

With methanol; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: 381236-49-3
1-(4-fluoro-3-methoxyphenyl)-N-methylmethanamine

: 1255924-32-3
4-(3,4-dichlorophenyl)-6-fluoro-7-(pyridin-2-yl)-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 9 steps

1.1: potassium carbonate / ethanol / 2.5 h / 20 °C

1.2: 0 °C

2.1: sulfuric acid / dichloromethane / 2.5 h / 0 - 20 °C

3.1: Chiralpak AD column / diethylamine; isopropyl alcohol / Resolution of racemate

4.1: hydrogen bromide; acetic acid / water / 110 °C / Inert atmosphere

5.1: pyridine / dichloromethane / 1 h / 0 °C

6.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 80 °C / Inert atmosphere

7.1: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; N,N-dimethyl-formamide / 2.5 h / 90 °C / Inert atmosphere

8.1: N,N,N',N'-tetramethyl-1,8-diaminonaphthalene / 1,2-dichloro-ethane / Reflux

9.1: methanol / 1 h / Reflux

With pyridine; methanol; sulfuric acid; hydrogen bromide; potassium acetate; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; potassium carbonate; caesium carbonate; acetic acid; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In ethanol; dichloromethane; water; dimethyl sulfoxide; 1,2-dichloro-ethane; diethylamine; N,N-dimethyl-formamide; isopropyl alcohol;