1-(3,4-dichlorophenyl)-2-((4-fluoro-3-methoxybenzyl)(methyl)amino)ethanol

Base Information

Chemical Name:1-(3,4-dichlorophenyl)-2-((4-fluoro-3-methoxybenzyl)(methyl)amino)ethanol
CAS No.:1255925-10-0
Molecular Formula:C₁₇H₁₈Cl₂FNO₂
Molecular Weight:358.24
Hs Code.:

Synonyms:1-(3,4-dichlorophenyl)-2-((4-fluoro-3-methoxybenzyl)(methyl)amino)ethanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(3,4-dichlorophenyl)-2-((4-fluoro-3-methoxybenzyl)(methyl)amino)ethanol

Chemical Property:

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Technology Process of 1-(3,4-dichlorophenyl)-2-((4-fluoro-3-methoxybenzyl)(methyl)amino)ethanol

There total 1 articles about 1-(3,4-dichlorophenyl)-2-((4-fluoro-3-methoxybenzyl)(methyl)amino)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 381236-49-3
1-(4-fluoro-3-methoxyphenyl)-N-methylmethanamine

: 2632-10-2
2-bromo-1-(3,4-dichlorophenyl)ethanone

: 1255925-10-0
1-(3,4-dichlorophenyl)-2-((4-fluoro-3-methoxybenzyl)(methyl)amino)ethanol

Guidance literature:: 1-(4-fluoro-3-methoxyphenyl)-N-methylmethanamine; 2-bromo-1-(3,4-dichlorophenyl)ethanone; With potassium carbonate; In ethanol; at 20 ℃; for 2.5h;

With sodium tetrahydroborate; at 0 ℃;

Reference yield: 98.0%

: 1255925-10-0
1-(3,4-dichlorophenyl)-2-((4-fluoro-3-methoxybenzyl)(methyl)amino)ethanol

: 1255925-11-1,1255925-13-3,1255925-14-4
4-(3,4-dichlorophenyl)-6-fluoro-7-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: With sulfuric acid; In dichloromethane; at 0 - 20 ℃; for 2.5h;

Reference yield:

: 1255925-10-0
1-(3,4-dichlorophenyl)-2-((4-fluoro-3-methoxybenzyl)(methyl)amino)ethanol

: (+)-7-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-6-fluoro-2-methyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 6 steps

1: sulfuric acid / dichloromethane / 2.5 h / 0 - 20 °C

2: Chiralpak AD column / diethylamine; isopropyl alcohol / Resolution of racemate

3: hydrogen bromide; acetic acid / water / 110 °C / Inert atmosphere

4: pyridine / dichloromethane / 1 h / 0 °C

5: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 80 °C / Inert atmosphere

6: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; N,N-dimethyl-formamide / 2.5 h / 90 °C / Inert atmosphere

With pyridine; sulfuric acid; hydrogen bromide; potassium acetate; caesium carbonate; acetic acid; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In dichloromethane; water; dimethyl sulfoxide; diethylamine; N,N-dimethyl-formamide; isopropyl alcohol;