3'-O-N₄-bis(4-methoxytrityl)-5'-C,5'-O-didehydro-2'-deoxy-2'-fluorocytidine

Base Information

Chemical Name:3'-O-N₄-bis(4-methoxytrityl)-5'-C,5'-O-didehydro-2'-deoxy-2'-fluorocytidine
CAS No.:1246253-30-4
Molecular Formula:C₄₉H₄₂FN₃O₆
Molecular Weight:787.887
Hs Code.:

3'-O-N<sub>4</sub>-bis(4-methoxytrityl)-5'-C,5'-O-didehydro-2'-deoxy-2'-fluorocytidine

Synonyms:3'-O-N₄-bis(4-methoxytrityl)-5'-C,5'-O-didehydro-2'-deoxy-2'-fluorocytidine

Suppliers and Price of 3'-O-N₄-bis(4-methoxytrityl)-5'-C,5'-O-didehydro-2'-deoxy-2'-fluorocytidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3'-O-N₄-bis(4-methoxytrityl)-5'-C,5'-O-didehydro-2'-deoxy-2'-fluorocytidine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3'-O-N₄-bis(4-methoxytrityl)-5'-C,5'-O-didehydro-2'-deoxy-2'-fluorocytidine

There total 4 articles about 3'-O-N₄-bis(4-methoxytrityl)-5'-C,5'-O-didehydro-2'-deoxy-2'-fluorocytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.7%

: 1246253-29-1
3'-O-N₄-bis(4-methoxytrityl)-2'-deoxy-2'-fluorocytidine

: 1246253-30-4
3'-O-N₄-bis(4-methoxytrityl)-5'-C,5'-O-didehydro-2'-deoxy-2'-fluorocytidine

Guidance literature:: With pyridine; Dess-Martin periodane; In dichloromethane; at 0 - 20 ℃; for 2h; Inert atmosphere;

Reference yield:

: 1246253-28-0
3'-O-N₄-bis(4-methoxytrityl)-5'-O-(t-butyldimethylsilyl)-2'-deoxy-2'-fluorocytidine

: 1246253-30-4
3'-O-N₄-bis(4-methoxytrityl)-5'-C,5'-O-didehydro-2'-deoxy-2'-fluorocytidine

Guidance literature:: Multi-step reaction with 2 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

2: trifluoroacetic acid; dicyclohexyl-carbodiimide; dimethyl sulfoxide; pyridine / 30 °C / Inert atmosphere

With pyridine; tetrabutyl ammonium fluoride; dimethyl sulfoxide; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; 2: |Pfitzner-Moffatt Oxidation;

Reference yield:

: 10212-20-1
2'-deoxy-2'-fluorocytidine

: 1246253-30-4
3'-O-N₄-bis(4-methoxytrityl)-5'-C,5'-O-didehydro-2'-deoxy-2'-fluorocytidine

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / 16 h / 20 °C / Cooling with ice

2: 2,4,6-trimethyl-pyridine; silver nitrate / dichloromethane / 16 h / 20 °C

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

4: trifluoroacetic acid; dicyclohexyl-carbodiimide; dimethyl sulfoxide; pyridine / 30 °C / Inert atmosphere

With pyridine; 2,4,6-trimethyl-pyridine; tetrabutyl ammonium fluoride; silver nitrate; dimethyl sulfoxide; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; 4: |Pfitzner-Moffatt Oxidation;