2'-Deoxy-2'-fluorocytidine

Base Information

Chemical Name:2'-Deoxy-2'-fluorocytidine
CAS No.:10212-20-1
Molecular Formula:C9H12FN3O4
Molecular Weight:245.21
Hs Code.:29389090
UNII:LCY080JPY9
Nikkaji Number:J556.916H
Wikidata:Q27282917
ChEMBL ID:CHEMBL374528
Mol file:10212-20-1.mol

Synonyms:2'-deoxy-2'-fluorocytidine;2'-fluoro-2'-deoxycytidine

Suppliers and Price of 2'-Deoxy-2'-fluorocytidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2’-Deoxy-2’-fluoroCytidine
10g
$ 525.00

TRC
2’-Deoxy-2’-fluoroCytidine
2g
$ 145.00

TCI Chemical
2'-Deoxy-2'-fluorocytidine Hydrate >98.0%(T)
1g
$ 126.00

SynQuest Laboratories
2'-Deoxy-2'-fluorocytidine
250 mg
$ 65.00

SynQuest Laboratories
2'-Deoxy-2'-fluorocytidine
5 g
$ 295.00

Medical Isotopes, Inc.
2?-Deoxy-2?-fluorocytidine 98%purewithdatedHPLCUVchromatogram
5 mg
$ 935.00

Medical Isotopes, Inc.
2?-Deoxy-2?-fluorocytidine 98%purewithdatedHPLCUVchromatogram
1 mg
$ 685.00

Matrix Scientific
4-Amino-1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one 95%
5g
$ 1355.00

Matrix Scientific
4-Amino-1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one 95%
1g
$ 452.00

Crysdot
2'-Deoxy-2'-fluorocytidine 98%
25g
$ 375.00

Total 133 raw suppliers

Chemical Property of 2'-Deoxy-2'-fluorocytidine

Chemical Property:

Appearance/Colour:White or almost white crystalline powder
Melting Point:167 °C
Refractive Index:80 ° (C=1, MeOH)
Boiling Point:500.1 °C at 760 mmHg
PKA:12.84±0.70(Predicted)
Flash Point:256.2 °C
PSA：110.60000
Density:1.82 g/cm³
LogP:-1.00460
Storage Temp.:2-8°C
Solubility.:Soluble in DMSO, Methanol.
XLogP3:-1.1
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:245.08118403
Heavy Atom Count:17
Complexity:386

Purity/Quality:

98%, ^*data from raw suppliers

2’-Deoxy-2’-fluoroCytidine ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 26-36

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CN(C(=O)N=C1N)C2C(C(C(O2)CO)O)F
Isomeric SMILES:C1=CN(C(=O)N=C1N)[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)F
Recent ClinicalTrials:Clinical Study to Compare the Efficacy and Safety of Macitentan and Tadalafil Monotherapies With the Corresponding Fixed-dose Combination Therapy in Subjects With Pulmonary Arterial Hypertension (PAH)
Recent EU Clinical Trials:A Phase 3 Evaluation of a daclatasvir/asunaprevir/BMS-791325 Fixed Dose Combination in Non-cirrhotic Subjects with Genotype 1 Chronic Hepatitis C
Uses 2'-Deoxy-2'-fluorocytidine is a potent inhibitor of the subgenomic hepatitis C virus replicon in Huh-7 cells. 2'-Deoxy-2'-fluorocytidine has been shown to inhibit Borna Disease virus replication and s pread. 2'-Fluoro-2'-deoxycytidine is a potent inhibitor of the subgenomic hepatitis C virus replicon in Huh-7 cells. 2'-Fluoro-2'-deoxycytidine has been shown to inhibit Borna Disease virus replication and spread.

Technology Process of 2'-Deoxy-2'-fluorocytidine

There total 14 articles about 2'-Deoxy-2'-fluorocytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 157024-78-7
9-<2-deoxy-2-fluoro-3,5-di-O-(tetrahydropyran-2-yl)-β-D-ribofuranosyl>cytosine

: 10212-20-1
2'-deoxy-2'-fluorocytidine

Guidance literature:: With ethanol; pyridinium p-toluenesulfonate; for 24h; Heating;
DOI:10.1248/cpb.42.595

Reference yield: 56.0%

: 3',5'-Di-O-benzoyl-2'-desoxy-2'-fluorcytidin

: 10212-20-1
2'-deoxy-2'-fluorocytidine

Guidance literature:: With ammonium hydroxide; at 50 ℃;

Reference yield:

: 56287-17-3,69123-94-0,784-71-4
2'-deoxy-2'-fluorouridine

: 10212-20-1
2'-deoxy-2'-fluorocytidine

Guidance literature:: Multi-step reaction with 4 steps

1: 92 percent / pyridine / 2 h / Ambient temperature

2: (PhO)2POCl, Et₃N / acetonitrile / 1.5 h / Ambient temperature

3: 32percent aq. NH₃ / dioxane / 0.33 h

4: EtNMe₂ / methanol / 24 h / 50 °C

With ammonium hydroxide; N,N-dimethyl-ethanamine; triethylamine; chlorophosphoric acid diphenyl ester; In 1,4-dioxane; pyridine; methanol; acetonitrile;
DOI:10.1002/hlca.19970800614